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Nanodrug applications in photodynamic therapy

机译：纳米药物在光动力疗法中的应用

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摘要

Photodynamic therapy (PDT) has developed over last century and is now becoming a more widely used medical tool having gained regulatory approval for the treatment of various diseases such as cancer and macular degeneration. It is a two-step technique in which the delivery of a photosensitizing drug is followed by the irradiation of light. Activated photosen-sitizers transfer energy to molecular oxygen which results in the generation of reactive oxygen species which in turn cause cells apoptosis or necrosis. Although this modality has significantly improved the quality of life and survival time for many cancer patients it still offers significant potential for further improvement. In addition to the development of new PDT drugs, the use of nanosized carriers for photosensitizers is a promising approach which might improve the efficiency of photodynamic activity and which can overcome many side effects associated with classic photodynamic therapy. This review aims at highlighting the different types of nanomedi-cal approaches currently used in PDT and outlines future trends and limitations of nanodelivery of photosensitizers.
机译：光动力疗法（PDT）在上个世纪已经发展起来，现在正成为一种更广泛使用的医疗工具，已获得监管机构的批准，可用于治疗各种疾病，例如癌症和黄斑变性。这是两步技术，其中在光敏药物的输送之后进行光照射。活化的光敏增粘剂将能量转移至分子氧，从而导致产生活性氧，进而导致细胞凋亡或坏死。尽管这种方式已大大改善了许多癌症患者的生活质量和生存时间，但仍具有进一步改善的巨大潜力。除了开发新的PDT药物外，将纳米级载体用于光敏剂也是一种很有前途的方法，它可以提高光动力活性的效率，并且可以克服与经典光动力疗法相关的许多副作用。这篇综述旨在突出PDT中当前使用的不同类型的纳米医学方法，并概述光敏剂纳米递送的未来趋势和局限性。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2011年第1期|p.14-29|共16页
  • 作者

    Edyta Paszko; Carsten Ehrhardt; Mathias O. Senge; Dermot P. Kelleher; John V. Reynolds;

  • 作者单位

    Medicinal Chemistry, Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland;

    School of Pharmacy & Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland;

    Medicinal Chemistry, Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland ,School of Chemistry, SFI Tetrapyrrole Laboratory, Trinity College Dublin, Dublin 2, Ireland;

    Clinical Medicine, Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland;

    Department of Clinical Surgery, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital,Dublin 8, Ireland;

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  • 正文语种 eng
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  • 关键词

    photodynamic therapy; photosensitizers; nanomedfcfne; nanoparticles; pharmaceutical nanocarriers; drug delivery; drug-conjugates;

    机译：光动力疗法;光敏剂;去甲肾上腺素;纳米颗粒;药物纳米载体;药物输送;药物结合物;

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