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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >An investigation of the fluorescence induced by topical application of 5-aminolaevulinic acid and methyl aminolaevulinate at different body sites on normal human skin
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An investigation of the fluorescence induced by topical application of 5-aminolaevulinic acid and methyl aminolaevulinate at different body sites on normal human skin

机译：在正常人皮肤不同部位局部应用5-氨基戊酸和甲基氨基戊酸甲酯诱导的荧光的研究

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Background: Although discovered over a century ago it is only in the last 25 years that photody-namic therapy (PDT) has been the focus of intense research. This versatile treatment modality has been shown to be effective in treating a wide variety of malignancies, and with the increasing incidence of non-melanoma skin cancer (NMSC) is a recognised treatment in dermatology clinics worldwide. There is little known as to whether different body sites influence the uptake and conversion of 5-aminolaevulinic acid (ALA) or methyl aminolaevulinate (MAL) to protopor-phyrin IX (PplX). In this study we investigated the characteristics of PplX fluorescence within normal skin following the application of both ALA and MAL to four different body sites and the effect of tape stripping. Methods: A total of 17 healthy volunteers were recruited, and both ALA and MAL were applied to the inner forearm, outer forearm, lower leg and back for 4 h. PplX fluorescence was detected using a non-invasive spectroscopy system. Results and conclusions: PplX fluorescence (following the application of either ALA or MAL) does vary significantly at different body sites with the lower leg producing the least. Following the application of ALA, peak fluorescence was noted at all body sites at 24 h, except the lower leg, which peaked at 7h. In contrast MAL induced fluorescence at all body sites, peaked earlier at 7h and had significantly decreased by 24 h. Removal of the stratum corneum by tape stripping was also shown to significantly increase PplX fluorescence but did not alter the time course.
机译：背景：尽管在一个多世纪前就被发现，但直到最近25年，光动力疗法（PDT）才成为了研究的重点。事实证明，这种多功能的治疗方式可有效治疗多种恶性肿瘤，并且随着非黑素瘤皮肤癌（NMSC）发病率的上升，全世界皮肤病学诊所都认可这种治疗方法。关于不同的身体部位是否会影响5-氨基松香酸（ALA）或氨基松香酸甲酯（MAL）转化为原卟啉IX（PplX）的了解很少。在这项研究中，我们研究了将ALA和MAL应用于四个不同的身体部位后正常皮肤中PplX荧光的特征以及胶带剥离的作用。方法：共招募了17名健康志愿者，分别对前臂内侧，前臂外侧，小腿和背部施加ALA和MAL，持续4 h。使用非侵入性光谱系统检测PplX荧光。结果与结论：PplX荧光（在使用ALA或MAL的情况下）在不同的身体部位确实有显着变化，小腿产生的荧光最少。施用ALA后，除小腿在7h达到峰值外，在24小时的所有身体部位都出现了峰值荧光。相比之下，MAL在所有身体部位诱导的荧光，在7h达到峰值，到24 h明显下降。还显示通过胶带剥离去除角质层显着增加了PplX荧光，但没有改变时间进程。

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