• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Optimal light dose and drug dosage in the photodynamic treatment using PHOTOCYANINE
【24h】

Optimal light dose and drug dosage in the photodynamic treatment using PHOTOCYANINE

机译：邻苯二甲胺光动力学治疗中的最佳光剂量和药物剂量

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: To explore the effective dose range of PHOTOCYANINE, the intensity and duration of irradiation using a 670-nm laser, and changes of local tissues after photodynamic therapy (PDT) in mice with S180 tumors to provide evidence for the clinical application of PDT. Basic methods: Kunming mice were administered the photosensitizer PHOTOCYANINE. After the administration of PHOTOCYANINE, irradiation with 670-nm laser had a remarkable inhibitory effect on the growth of the grafted tumor S180.Main results: Within the power densities 36—144 J/cm2, the irradiation dose showed a significant dose—response relationship; under the same drug dosage, an increase in irradiation dose could enhance the inhibitory effect on tumor growth. In the groups administered PHOTOCYANINE and irradiated with a 670-nm laser, the temperature of the local surface did not increase remarkably, an effect also seen in the negative control group. Local swelling around the tumor occurred immediately after PHOTOCYANINE administration and laser irradiation, and could last for about 3 days. Vertical resection of the tumors 72 h after irradiation showed that the depth of local-tissue necrosis after PHOTOCYANINE administration and laser irradiation was 5.7-7.5 mm. Phncipal condusions: The efficacy of PHOTOCYANINE was significantly correlated with its dose; under identical irradiation conditions, the increase in drug dose increased the tumor inhibition rate (TIR) within a certain dose range. The efficacy of PHOTOCYANINE also showed significant irradiation-dependent characteristics.
机译：背景：探讨光敏花青素的有效剂量范围，670 nm激光的照射强度和持续时间，以及光动力疗法（PDT）对S180肿瘤小鼠的局部组织变化，为PDT的临床应用提供证据。基本方法：给昆明小鼠施用光敏剂光氰酸。施用酞菁后，用670 nm激光辐照对移植瘤S180的生长具有显着的抑制作用。主要结果：在功率密度36-144 J / cm2内，辐照剂量显示出显着的剂量反应关系。 ;在相同药物剂量下，增加放射剂量可以增强对肿瘤生长的抑制作用。在用酞菁和670nm激光照射的组中，局部表面的温度没有显着升高，在阴性对照组中也看到了这种效果。施用酞菁和激光照射后，肿瘤周围立即发生局部肿胀，可能持续约3天。放射线照射72 h后垂直切除肿瘤，经光合作用和激光照射后，局部组织坏死的深度为5.7-7.5 mm。主要表现：酞菁的功效与其剂量密切相关；在相同的照射条件下，药物剂量的增加在一定剂量范围内增加了肿瘤抑制率（TIR）。酞菁的功效还显示出显着的辐射依赖性特征。

著录项

  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2011年第3期|p.267-274|共8页
  • 作者

    Jinping Xue; Chao Li; Hong Liu; Jinfeng Wei; Naisheng Chen; Jinling Huang;

  • 作者单位

    Institute of Research on Functional Materials, Collese of Chemistry and Chemkal Engineerins, Fuzhou University,Fuzhou 350002, PR China;

    rnNew Drug Safety Evaluation Center in Chinese Academy of Medical Sciences & Peking Union Medical CoUege,Beijing 100050, PR China;

    rnInstitute of Research on Functional Materials, Collese of Chemistry and Chemkal Engineerins, Fuzhou University,Fuzhou 350002, PR China;

    rnNew Drug Safety Evaluation Center in Chinese Academy of Medical Sciences & Peking Union Medical CoUege,Beijing 100050, PR China;

    rnInstitute of Research on Functional Materials, Collese of Chemistry and Chemkal Engineerins, Fuzhou University,Fuzhou 350002, PR China;

    rnInstitute of Research on Functional Materials, Collese of Chemistry and Chemkal Engineerins, Fuzhou University,Fuzhou 350002, PR China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    PHOTOCYANINE; Photodynamic therapy; Light dose; Drug dosage; Phthalocyanine;

    机译：酞菁;光动力疗法;轻剂量;药物剂量酞菁;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号