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A dedicated applicator for light delivery and monitoring of PDT of intra-anal intraepithelial neoplasia

机译：用于肛门内上皮内瘤变的PDT的光传输和PDT监测的专用涂药器

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The objective of this study was to develop an applicator for delivery of light and monitoring of photodynamic therapy (PDT) in the anal cavity for treatment of anal intraepithelial neoplasia grade III (AIN III), which can progress to invasive anal cancer.rnForty-eight hours before treatment, patients participating in the study were injected with 0.03 (n = 2) or 0.075 (n = 2) mg kg~(-1) m-THPC. For light delivery and monitoring of PDT, an applicator based on standard anoscopy equipment was developed which facilitates, in addition to a light treatment fiber, fiber optic probes to monitor blood saturation, blood volume, fluorescence and fluence (rate) at two different locations in situ. Patients were given a light dose of 10-17 J cm~2 at a fluence rate of 45-50 mW cm~2 based on in situ measured light treatment parameters.rnWe demonstrate that the applicator does not influence the fluence rate profile of the light treatment fiber. Furthermore this study shows the possibility of monitoring blood saturation, blood volume, fluorescence and fluence (rate) during therapeutic illumination without changing the light treatment protocol.
机译：这项研究的目的是开发一种用于在肛门腔内传输光和监测光动力疗法（PDT）的涂药器，以治疗可能发展为浸润性肛门癌的III级肛门上皮内瘤变（AIN III）.rn在治疗前数小时，参加研究的患者注射0.03（n = 2）或0.075（n = 2）mg kg〜（-1）m-THPC。为了光传输和监测PDT，开发了一种基于标准肛门镜设备的涂药器，该涂药器除了使用光处理纤维外，还促进了光纤探针以监测血液中两个不同位置的血饱和度，血容量，荧光和通量（速率）。原地。根据现场测量的光治疗参数，以45-50 mW cm〜2的注量速率为患者提供10-17 J cm〜2的光剂量.rn我们证明施药器不会影响光的注量率分布。处理纤维。此外，这项研究表明，在不改变光疗方案的情况下，可以在治疗性照明过程中监测血液饱和度，血容量，荧光和能量密度（速率）的可能性。

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