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Effect of MAL-photodynamic therapy on hypertrophic scarring

机译：MAL光动力疗法对肥厚性瘢痕的影响

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Background: Patients with localised scleroderma receiving aminolevulinic acid (ALA)/methyl aminolevulinic acid (MAL)-photodynamic therapy (PDT) were noted to show a reduction in skin tightness, suggesting that this therapy reduces skin sclerosis [1]. Karrer and colleagues treated patients with 5-ALA-PDT once or twice weekly for 3-6 months and in all patients the therapy was reported to be highly effective for sclerotic plaques.rnIn view of the potential benefit of PDT in reducing skin sclerosis, the following study looks at the possible clinical and histological effects of topical PDT on the mechanism of scarring, looking particularly at hypertrophic scars.rnMethods: Patients with long standing hypertrophic scars were treated with MAL-PDT on two occasions at week apart, and repeated for 3 sessions at 6-weekly intervals. PDT effect was studied by means of fluorescence imaging throughout the treatment and biopsies were taken prior to and 6 weeks post-treatment to observe histological changes.rnResults and conclusions: Six weeks following the treatment the scarred areas had significantly softened and become more flexible clinically and histologically there had been a significant increase in elastin fibres.rnThis suggests that ALA/MAL-PDT may be a useful treatment or adjuvant therapy in the treatment of scarring.
机译：背景：局限性硬皮病患者接受氨基乙酰丙酸（ALA）/甲基氨基乙酰丙酸（MAL）-光动力疗法（PDT）的治疗表明皮肤紧致度降低，表明该疗法可减轻皮肤硬化[1]。 Karrer及其同事每周一次或两次用5-ALA-PDT治疗3-6个月，据报道在所有患者中该疗法对硬化斑块都是非常有效的。考虑到PDT在减少皮肤硬化方面的潜在益处，以下研究着眼于局部PDT对瘢痕形成机制的可能的临床和组织学影响，尤其是肥厚性瘢痕.rn方法：长期站立肥厚性瘢痕患者每周两次接受MAL-PDT治疗，重复3次每6周一次的会议。在整个治疗过程中，通过荧光成像研究PDT的效果，并在治疗前和治疗后6周进行活检以观察组织学变化。rn结果与结论：治疗6周后，疤痕部位明显软化，临床上变得更加柔软。从组织学上讲，弹性蛋白纤维显着增加。这表明ALA / MAL-PDT在瘢痕形成治疗中可能是有用的治疗方法或辅助治疗方法。

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