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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological methyl-aminolevulinate photodynamic therapy
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Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological methyl-aminolevulinate photodynamic therapy

机译：标准皮肤病学氨基乙酰丙酸光动力疗法光照射阶段的原卟啉IX光漂白

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摘要

Background: Methyl-aminolevulinate photodynamic therapy (MAL-PDT) is a successful treatment for non-melanoma skin cancers in the UK. Monitoring the photobleaching of the photosensitiser, protoporphyrin IX (PplX) during treatment has been demonstrated to indicate the efficacy of the treatment. This study investigated photobleaching during light irradiation. Methods: A validated non-invasive fluorescence imaging system was utilised to monitor changes in PplX fluorescence during light irradiation. Fifty patients were recruited to this study, with patients monitored before, during (forty patients at the half way stage and ten at regular intervals in the initial phase of treatment) and after light irradiation. Results: Phased PplX photobleaching was observed during light irradiation with a significantly greater change (P< 0.001) in PplX photobleaching during the first half of light treatment. Within the ten patients monitored periodically the phased photobleaching observed fitted a double exponential decay curve (r~2 = 0.99, P<0.005) suggesting a rapid initial phase of reaction when the light treatment was commenced. Conclusions: Photobleaching was observed to be maximal in the initial phases of treatment, however photobleaching of PplX continued until the completion of light treatment indicating that current clinical protocols for MAL-PDT do not over-treat the lesion with light.
机译：背景：氨基乙酰丙酸甲酯光动力疗法（MAL-PDT）是英国非黑色素瘤皮肤癌的成功疗法。已经证明，在治疗过程中监测光敏剂原卟啉IX（PplX）的光漂白可表明治疗效果。这项研究调查了光照射期间的光漂白。方法：利用经过验证的非侵入式荧光成像系统监测光照射过程中PplX荧光的变化。招募了50名患者，并在光照射之前，期间（在治疗的初期，有40名患者处于中间阶段，有10名患者以定期间隔）对患者进行了监测。结果：在光照射期间观察到分阶段的PplX光漂白，在光处理的前半段中PplX光漂白的变化显着更大（P <0.001）。在定期监测的十名患者中，观察到的分阶段光漂白拟合了双指数衰减曲线（r〜2 = 0.99，P <0.005），表明开始光疗后反应开始迅速。结论：在治疗的初始阶段观察到光漂白是最大的，但是PplX的光漂白一直持续到光治疗完成为止，这表明目前MAL-PDT的临床方案并未对光进行过度治疗。

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