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首页> 外文期刊>Journal of environmental pathology, toxicology and oncology: official organ of the International Society for Environmental Toxicology and Cancer >Fluorescence photobleaching of ALA and ALA-heptyl ester induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: a comparison of two light sources and different illumination schemes.
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Fluorescence photobleaching of ALA and ALA-heptyl ester induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: a comparison of two light sources and different illumination schemes.

机译：正常无毛小鼠皮肤光动力治疗过程中ALA和ALA-庚酯诱导的原卟啉IX的荧光光漂白：两种光源和不同照明方案的比较。

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摘要

This study investigated photobleaching of protoporphyrin IX (PpIX) induced by 5-aminolevulinic acid (ALA) and ALA-heptyl ester during superficial photodynamic therapy (PDT) in normal skin of the female BALB/c-nu/nu athymic mouse. We examined the effects of two light sources (laser and broadband lamp) and two different illumination schemes (fractionated light and continuous irradiation) on the kinetics of photobleaching. Our results show that light exposure (0-30 minutes, 10 mW/cm2) of wavelengths of approximately 420 nm (blue light) and 635 nm (red light) induced time-dependent PpIX photobleaching for mouse skin of 2% ALA and ALA-heptyl ester. Blue light (10 mW/cm2) caused more rapid PpIX photobleaching than did red light (100 mW/cm2), which is attributed to stronger absorption at 407 nm than at 632 nm for PpIX. In the case of light fractionation, fractionated light induced faster photobleaching compared with continuous light exposure after topical application of 2% ALA and ALA-heptyl ester in vivo. These have been suggested to allow reoxygenation of the irradiated tissue, with a consequent enhancement of singlet oxygen production in the second and subsequent fractions.
机译：这项研究调查了雌性BALB / c-nu / nu无胸腺小鼠的正常皮肤在浅层光动力疗法（PDT）期间由5-氨基乙酰丙酸（ALA）和ALA-庚酯引起的原卟啉IX（PpIX）的光漂白。我们研究了两种光源（激光和宽带灯）和两种不同的照明方案（分光和连续照射）对光漂白动力学的影响。我们的结果表明，大约420 nm（蓝光）和635 nm（红光）波长的光暴露（0-30分钟，10 mW / cm2）导致2％ALA和ALA-庚酯。蓝光（10 mW / cm2）引起的PpIX光致漂白比红光（100 mW / cm2）更快，这归因于PpIX在407 nm处的吸收强于632 nm。在光分馏的情况下，与在体内局部应用2％ALA和ALA-庚酯后连续曝光相比，分馏光诱导了更快的光致漂白。已经提出这些可以使被辐照的组织再充氧，从而在第二和随后的馏分中提高单线态氧的产生。

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