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首页> 外文期刊>Photodiagnosis and photodynamics therapy >The optimization of fluorescence imaging of brain tumor tissue differentiated from brain edema-In vivo kinetic study of 5-aminolevulinic acid and talaporfin sodium
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The optimization of fluorescence imaging of brain tumor tissue differentiated from brain edema-In vivo kinetic study of 5-aminolevulinic acid and talaporfin sodium

机译：脑水肿分化脑肿瘤组织荧光成像的优化-5-氨基乙酰丙酸和他拉泊芬钠的体内动力学研究

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摘要

Objective: We aimed to clarify the optimal timing for the fluorescence imaging of brain tumor tissue differentiated from brain edema after the administration of photosensitizers. Methods: We have performed an in vivo study of the kinetics of 5-aminolevulinic acid (5-ALA) in comparison with talaporfin sodium using the rat brain tumor model and rat vasogenic edema model produced by cold injury. The in vivo kinetics of 5-ALA and talaporfin sodium in brain tumor model and the vasogenic edema model was determined by a fluorescence macroscope and a microplate reader.rnResults: The in vivo kinetic study of 5-ALA showed mild fluorescence intensity of protoporphyrin IX (PpIX) in brain tumor differentiated from vasogenic edema. The mean lesion-to-normal-brain ratio (L/N ratio) in the group of brain tumor model 2h after the administration of 5-ALA was 7.78 ±4.61, which was significantly higher (P<0.01) than that of the vasogenic edema 2 h after the administration of 5-ALA (2.75 ± 1.12). In vivo kinetic study of talaporfin sodium showed high fluorescence intensity and retention in brain tumor differentiated from vasogenic edema. The mean L/N ratio of the fluorescence intensity in the group of brain tumor model 12 h after the administration of talaporfin sodium was 23.1 ±11.9, which was significantly higher (P<0.01) than that of the vasogenic edema 12 h after the administration (8.93 ±8.03). Conclusions: The optimization of fluorescence imaging of brain tumors differentiated from brain edema is possible in the case of 5-ALA within 6h, and also possible in the case of talaporfin sodium beyond 12 h.
机译：目的：我们旨在阐明在使用光敏剂后脑肿瘤从脑水肿中分化出来的荧光成像的最佳时机。方法：我们使用大鼠脑肿瘤模型和冷损伤产生的大鼠血管性水肿模型，对5-氨基乙酰丙酸（5-ALA）与他拉泊芬钠的动力学进行了体内研究。用荧光显微镜和酶标仪测定5-ALA和他拉泊芬钠在脑肿瘤模型和血管性水肿模型中的体内动力学。结果：5-ALA的体内动力学研究显示原卟啉IX（（ PpIX）在脑肿瘤中与血管性水肿区分开来。 5-ALA给药后2h，脑肿瘤模型组的平均病变与正常脑的比率（L / N比）为7.78±4.61，比血管生成的显着更高（P <0.01）。服用5-ALA后2小时出现水肿（2.75±1.12）。他拉泊芬钠的体内动力学研究显示高荧光强度和在脑血管瘤中与血管源性水肿区分开的保留。塔拉泊芬钠给药12 h后脑肿瘤模型组的荧光强度平均L / N比为23.1±11.9，显着高于给药12 h血管生成性水肿的荧光强度（P <0.01）。 （8.93±8.03）。结论：在6h内使用5-ALA可以优化脑肿瘤与脑水肿相鉴别的荧光成像，在12h内使用他拉泊芬钠也可以优化荧光成像。

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  • 来源
    《Photodiagnosis and photodynamics therapy》 |2009年第1期|19-27|共9页
  • 作者

    Takao Tsurubuchi; Alexander Zoboronok; Tetsuya Yamamoto; Kei Nakai; Fumiyo Yoshida; Makoto Shirakawa; Masahide Matsuda; Akira Matsumura;

  • 作者单位

    Department of Neurosursery, Institute of Clinical Medicine, University of Tsukuba, Japan;

    Department of Neurosursery, Institute of Clinical Medicine, University of Tsukuba, Japan;

    Department of Neurosursery, Institute of Clinical Medicine, University of Tsukuba, Japan;

    Department of Neurosursery, Institute of Clinical Medicine, University of Tsukuba, Japan;

    Department of Neurosursery, Institute of Clinical Medicine, University of Tsukuba, Japan;

    1-1-1 Tennodai, Tsukuba City, Ibaraki Prefecture, #305-8575, Japan;

    Department of Neurosursery, Institute of Clinical Medicine, University of Tsukuba, Japan;

    Department of Neurosursery, Institute of Clinical Medicine, University of Tsukuba, Japan;

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  • 关键词

    brain; glioma; PD; PDT Rat model;

    机译：脑;胶质瘤PD;PDT和大鼠模型;

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