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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Different pain sensations in photodynamic therapy of nodular basal cell carcinoma Results from a prospective trial and a review of the literature
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Different pain sensations in photodynamic therapy of nodular basal cell carcinoma Results from a prospective trial and a review of the literature

机译：结节性基底细胞癌光动力治疗中的不同疼痛感觉来自一项前瞻性试验和文献综述

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Background: Pain is a major side effect of topical photodynamic therapy (PDT), a relatively new and non-invasive treatment for particular types of basal cell carcinoma (BCC). In this study, we sought to characterise in more detail the quality and intensity of pain associated with PDT. Furthermore, we studied if gender, tumour size and localization as well as different light sources with comparable wavelengths had an influence on the pain. Methods: A total of 64 nodular BCCs in 55 patients, of which 48 BCCs underwent preceding debulking, were treated with 5-aminolevulinic acid (ALA-PDT). Two metal halogen light sources were randomly used. Pain assessment was performed using a visual analogue scale (VAS). Results: All patients experienced pain during illumination and 41.8% after illumination. The mean pain intensity was 3.88 with most patients experiencing burning (82.5%) or stinging (36.8%) sensations. Illumination with the Medeikonos~® light source was experienced less painful than the Waldmann~® lamp (4.64 versus 3.40; p = 0.027). Gender as well as tumour localization and size did not alter the pain scores. Likewise, no differences were observed between patients who underwent debulking and those who did not. Conclusions: Treatment of single BCCs with ALA-PDT rarely results in unbearable pain. However, the degree of pain can vary depending on the light source used. Further studies are needed to unravel the pathomechanisms underlying the development of pain in PDT in order to develop adequate solutions for this undesirable side effect.
机译：背景：疼痛是局部光动力疗法（PDT）的主要副作用，局部光动力疗法是针对特定类型的基底细胞癌（BCC）的一种相对较新的无创治疗方法。在这项研究中，我们试图更详细地描述与PDT相关的疼痛的质量和强度。此外，我们研究了性别，肿瘤大小和位置以及具有可比波长的不同光源是否对疼痛有影响。方法：对55例患者中的64个结节性BCCs进行了5-氨基乙酰丙酸（ALA-PDT）治疗，其中48个BCC在减体前接受了治疗。随机使用两个金属卤素灯光源。使用视觉模拟量表（VAS）进行疼痛评估。结果：所有患者在照明过程中均经历疼痛，且在照明后达到41.8％。平均疼痛强度为3.88，大多数患者感到烧灼（82.5％）或刺痛（36.8％）。使用Medeikonos®光源进行照明的痛苦要比Waldmann®®灯泡减轻（4.64对3.40； p = 0.027）。性别以及肿瘤的位置和大小均未改变疼痛评分。同样，接受减重的患者与未接受减重的患者之间也未观察到差异。结论：用ALA-PDT治疗单个BCC很少会导致难以忍受的疼痛。但是，疼痛程度可能会因所使用的光源而异。需要进一步的研究来揭示PDT疼痛发展的潜在机制，以便为这种不良副作用找到适当的解决方案。

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