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Photodynamic therapy in the management of a patient with Gorlin syndrome (naevoid basal cell carcinoma syndrome)

机译:光动力疗法治疗高林综合症(无回避性基底细胞癌综合症)的患者

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摘要

Gorlin syndrome (naevoid basal cell carcinoma syndrome) is a genetically linked disorder characterized by the development of multiple basal cell carcinomas (BCCs) throughout life. Cumulative surgery, cryotherapy and other conventional interventions can result in significant disfigurement by middle age. Radiotherapy is contra-indicated because the mutated gene underlying the syndrome, 'PTCH', increases sensitivity to ionising radiation, so there is significant likelihood of inducing further tumours in and around the irradiated area. Photodynamic therapy offers a non-invasive treatment option for patients with this condition, with the added advantage of causing minimal scarring.
机译:高林综合症(无回避性基底细胞癌综合症)是一种遗传相关疾病,其特征是一生中会发展为多种基底细胞癌(BCC)。累积手术,冷冻疗法和其他常规干预措施可能导致中年人的容貌明显恶化。禁忌放疗,因为该综合征的突变基因“ PTCH”增加了对电离辐射的敏感性,因此很有可能在受辐照区域内和周围诱发更多的肿瘤。光动力疗法为患有这种疾病的患者提供了一种非侵入性的治疗选择,其附加优点是可减少疤痕。

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