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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Investigating the photo-thermo-radiosensitization effects of folate-conjugated gold nanorods on KB nasopharyngeal carcinoma cells
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Investigating the photo-thermo-radiosensitization effects of folate-conjugated gold nanorods on KB nasopharyngeal carcinoma cells

机译：研究叶酸偶联金纳米棒对KB鼻咽癌细胞的光热放射增敏作用

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摘要

In this article, we report a targeted cancer treatment strategy using nano-photo-thermal therapy (NPTT) and radiotherapy (RT) methods.Gold nanorods (AuNRs) without and with folic acid (FA) conjugation were firstly synthesized and then characterized. Cytotoxicity of various methods; NPTT (nanoparticles; 808 nm laser; 2 W/cm(2)) or RT MV X-ray; 2 Gy) or combination of NPTT and RT; was separately investigated on KB nasopharyngeal carcinoma cells. The effects of different treatments were studies using MTT assay, inductively coupled plasma-mass spectrometry (ICP-MS) and transmission electron microscopy (TEM).Both TEM and ICP-MS confirmed the internalization of nanoparticles into the KB cells. ICP-MS analysis revealed that AuNR-FA cell uptake was higher than AuNRs. Viability of the cells received NPTT was lower than those cells received laser or nanoparticles alone. Furthermore, it was found that combination of NPTT and RT notably decreased the viability of KB cells. Following such a combinatorial treatment (NPTT + RT), intensive damages were identified in TEM images obtained from treated cells.It may be concluded that AuNR-FA nanoconjugate is a good candidate to be used as a targeted sensitizer agent for nano-photo-thermo-radiotherapy of head and neck cancer cells.
机译：在本文中，我们报告了使用纳米光热疗法（NPTT）和放射疗法（RT）方法的靶向癌症治疗策略。首先合成并结合叶酸（FA）结合的金纳米棒（AuNRs）。各种方法的细胞毒性； NPTT（纳米粒子; 808 nm激光; 2 W / cm（2））或RT MV X射线; 2 Gy）或NPTT和RT的组合；对KB鼻咽癌细胞进行了单独研究。使用MTT法，电感耦合等离子体质谱法（ICP-MS）和透射电子显微镜（TEM）研究了不同处理的效果。TEM和ICP-MS均证实了纳米粒子被内化到KB细胞中。 ICP-MS分析表明，AuNR-FA细胞摄取高于AuNRs。接受NPTT的细胞的活力低于仅接受激光或纳米颗粒的细胞的活力。此外，发现NPTT和RT的组合显着降低了KB细胞的活力。经过这样的组合处理（NPTT + RT），在从处理过的细胞获得的TEM图像中发现了严重的损伤。可以得出结论，AuNR-FA纳米共轭物是用作纳米光热靶向敏化剂的良好候选者头颈癌细胞的放射疗法。

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