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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >A clinical evaluation of efficacy of photodynamic therapy in treatment of reticular oral lichen planus: A case series
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A clinical evaluation of efficacy of photodynamic therapy in treatment of reticular oral lichen planus: A case series

机译：光动力疗法治疗网状口腔扁平苔藓疗效的临床评估

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Background The aim of the study was to clinically evaluate the efficacy of photodynamic therapy in treatment of reticular oral lichen planus (OLP).Methods Fifty patients aged 26-84, with 124 OLP lesions in total, underwent photodynamic therapy (PDT) mediated with topically applied 5% 5-aminolevulinic acid. ALA was activated by a custom-made diode lamp with a high-power LED emitting light at 630 nm and 300 mW delivered through an optical fiber probe. A light exposure dose was 150 J/cm(2). The therapy comprised of 10 weekly illumination sessions. The lesions' response was macroscopically measured in millimeters with a periodontal probe and clinically evaluated at each session, then on completion of the series and throughout the 12-month follow-up.Results The baseline mean size of lesions was 3.99 cm(2) +/- 3.73. The lesions on the buccal mucosa and lips (lining mucosa) were larger than those on the gingiva and tongue (masticatory mucosa) - 4.58 cm(2) +/- 4.01 and 2.93 cm(2) +/- 2.91 respectively. On completion of the therapy 109 sites improved, including 46 in complete remission. The mean reduction in size was 62.91% (p = 0.000000). 12-month after therapy mean reduction of the lesions was 78.7% (p = 0.000000), specifically 79.48% (p = 0.000000) within the lining mucosa and 76.11% on the masticatory mucosa.Conclusions The results proved that ALA-mediated photodynamic therapy with a 630 nm light was effective and as such it can be used as an optional treatment for symptomatic OLP.
机译：背景研究的目的是临床评价光动力疗法治疗网状口腔扁平苔藓（OLP）的疗效。方法对50例年龄在26-84岁，共124个OLP病变的患者进行局部光动力疗法（PDT）的治疗。施用5％的5-氨基乙酰丙酸。 ALA由定制的二极管灯激活，该二极管灯带有大功率LED，该光纤通过光纤探头发出630 nm和300 mW的光。曝光剂量为150 J / cm（2）。该疗法包括每周10次照明课程。病变的反应用牙周探针以毫米为单位进行宏观测量，并在每次疗程中进行临床评估，然后在系列完成后以及整个12个月的随访中进行。结果病变的基线平均大小为3.99 cm（2）+ /-3.73。颊黏膜和嘴唇（衬里黏膜）上的病变大于牙龈和舌头（咀嚼性黏膜）上的病变-分别为4.58 cm（2）+/- 4.01和2.93 cm（2）+/- 2.91。治疗完成后，改善了109个部位，其中46个完全缓解。尺寸的平均减少为62.91％（p = 0.000000）。治疗后12个月，病变平均减少率为78.7％（p = 0.000000），特别是衬里粘膜内病变的减少率为79.48％（p = 0.000000），咀嚼性粘膜为76.11％。 630 nm的光是有效的，因此可以用作症状性OLP的可选治疗。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2019年第3期|50-57|共8页
  • 作者

    Sulewska Magdalena; Duraj Ewa; Sobaniec Stefan; Graczyk Alfreda; Milewski Robert; Wroblewska Marta; Pietruski Jan; Pietruska Malgorzata;

  • 作者单位

    Med Univ Bialystok, Dept Periodontal & Oral Mucosa Dis, Ul Waszyngtona 13, PL-15269 Bialystok, Poland;

    Med Univ Bialystok, Dept Periodontal & Oral Mucosa Dis, Ul Waszyngtona 13, PL-15269 Bialystok, Poland;

    Med Univ Bialystok, Dept Periodontal & Oral Mucosa Dis, Ul Waszyngtona 13, PL-15269 Bialystok, Poland;

    Mil Acad Technol, Inst Optoelect, Lab Biochem & Spect, Ul Gen Sylwestra Kaliskiego 2, PL-00908 Warsaw, Poland;

    Med Univ Bialystok, Dept Stat & Med Informat, Ul Szpitalna 37, PL-15295 Bialystok, Poland;

    Dent Practice, Ul Kardynala Wyszynskiego 16, PL-18400 Lomza, Poland;

    Dent Practice, Ul Waszyngtona 1-34, PL-15269 Bialystok, Poland;

    Med Univ Bialystok, Dept Periodontal & Oral Mucosa Dis, Ul Waszyngtona 13, PL-15269 Bialystok, Poland|Dent Practice, Ul Waszyngtona 1-34, PL-15269 Bialystok, Poland;

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  • 关键词

    Reticular oral lichen planus; Photodynamic therapy;

    机译：网状口腔扁平苔藓;光动力疗法;

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