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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Low-level light-assisted photodynamic therapy using a wearable cap-like device for the treatment of actinic keratosis of the scalp
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Low-level light-assisted photodynamic therapy using a wearable cap-like device for the treatment of actinic keratosis of the scalp

机译：使用可穿戴式帽状装置的低水平光辅助光动力疗法，用于治疗头皮光化性角化病

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Background: Daylight photodynamic therapy (dIPDT) is a painless and increasingly cost-effective treatment for actinic keratosis (AK). New protocols avoid incubation, minimizing pain and adverse events. However, it is time consuming and dependent on specific weather conditions. In patients with AK of the scalp, we evaluated the efficacy of indoor photodynamic therapy (PDT) using a wearable low-level light therapy (LLLT) device, without pre-incubation with a photosensitizing agent.Methods: In this pilot study, 27 patients with thin and moderately thick AK (Olsen Grades I-II) underwent a single 15-minute session of LLLT using a wearable cap-like device immediately after application of methyl aminolevulinate (MAL) cream, with no prior preparation of the affected area. Treatment efficacy was quantified by measuring the reduction in AK lesion number and the AK quality of life (AKQoL) score. All AK lesions were mapped at baseline for follow-up 2 months later. Paired pre/post scalp biopsies from 5 patients were analysed using histological and immunohistochemical techniques (p53, p27, cyclin D1, p63, and Ki67 expression). Data were analysed using the Wilcoxon signed-rank test.Results: In all patients we observed a global reduction in the number of AK lesions (71%; p 0.0001) and AKQoL score (from 5.6 to 4.4; p = 0.034) 2 months after treatment. Histology and immunohistochemistry of skin biopsies from 5 patients also revealed marked improvements after LLLT. No patients reported any pain during treatment.Conclusion: PDT using LLLT is a rapid, painless, and efficacious modality for the treatment of AK.
机译：背景：日光动力疗法（dIPDT）是一种无痛且成本效益更高的光化性角化病（AK）治疗。新的协议避免了孵化，最大限度地减少了痛苦和不良事件。但是，这很耗时，并且取决于特定的天气条件。在头皮AK的患者中，我们使用可穿戴的低水平光疗（LLLT）装置而不进行光敏剂预孵育的情况下评估了室内光动力疗法（PDT）的有效性。方法：在该初步研究中，有27例患者在使用氨基乙酰丙酸甲酯（MAL）乳霜后，立即使用可穿戴式帽状装置对瘦弱和中等厚的AK（Olsen I-II级）的LLLT进行15分钟的单次治疗，而无需事先准备患处。通过测量AK病变数目的减少和AK生活质量（AKQoL）评分来量化治疗效果。所有AK病变均在基线定位，并在2个月后进行随访。使用组织学和免疫组化技术（p53，p27，cyclin D1，p63和Ki67表达）分析了5例患者的配对头皮活检前后。结果：在所有患者中，我们观察到2个月时AK病变的数量（71％； p <0.0001）和AKQoL评分（从5.6到4.4； p = 0.034）总体减少了。治疗后。 5名患者的皮肤活检组织学和免疫组织化学也显示LLLT后有明显改善。没有患者在治疗期间报告任何疼痛。结论：使用LLLT的PDT是一种快速，无痛且有效的AK治疗方法。

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