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Photodynamic therapy for the treatment of oral squamous carcinoma-Clinical implications resulting from in vitro research

机译：光动力疗法治疗口腔鳞状细胞癌-体外研究的临床意义

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Background: Oral cavity squamous cell carcinoma is a common cancer of the head and neck region. Due to the frequency of diagnoses, high rate of mortality, mutilating nature of classic therapy and numerous complications, new methods of treatment are being sought. One promising solution for treatment which is utilized in many fields of oncology is photodynamic therapy. The purpose of this article is to present a general overview of the use of photodynamic therapy in preclinical in vitro studies.Materials and methods: A literature search for articles corresponding to the topic of this review was performed using the PubMed and MEDLINE databases using the following keywords: 'oral cavity squamous cell carcinoma,' 'photodynamic therapy,' photosensitizer(s),"in vitro,' cell culture(s),' spheroids,"CAM model', and 'in vivo.'Results: Most of the previous work found in the literature search concerns research on the use of various photosensitizers and the determination of their level of phototoxicity against cell lines.Concluding remarks: Research on the photodynamic effect in cell lines may be useful in establishing the mechanisms and effectiveness of the photodynamic method as a starting point for clinical trials. Studies on spheroidal models allows for testing photodynamic therapy under more clinical-like conditions. The Chick Chorioallantoic Membrane Assay provides information about the vascular changes after treatment.
机译：背景：口腔鳞状细胞癌是头部和颈部的常见癌症。由于诊断的频率，高死亡率，经典疗法的残废性和许多并发症，正在寻求新的治疗方法。在肿瘤学的许多领域中使用的一种有希望的治疗方案是光动力疗法。本文的目的是概述光动力疗法在临床前体外研究中的应用。材料和方法：使用PubMed和MEDLINE数据库通过以下方法对与本综述主题相对应的文章进行文献检索：关键词：“口腔鳞状细胞癌”，“光动力疗法”，“光敏剂”，“体外”，“细胞培养”，“球体”，“ CAM模型”和“体内”。结果：大多数以前在文献检索中发现的工作涉及对各种光敏剂的使用及其对细胞系的光毒性水平测定的研究。结论：细胞系中的光动力效应研究可能对建立光动力机制和有效性很有帮助。方法作为临床试验的起点。球体模型的研究可以在更像临床的条件下测试光动力疗法。小鸡绒毛膜尿囊化验可提供有关治疗后血管变化的信息。

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