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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Hematoporphyrin monomethyl ether photodynamic therapy for the treatment of facial port-wine stains resistant to pulsed dye laser
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Hematoporphyrin monomethyl ether photodynamic therapy for the treatment of facial port-wine stains resistant to pulsed dye laser

机译：血卟啉单甲基醚光动力疗法治疗面部斗葡萄酒污渍抗脉冲染料激光器

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Background: Pulsed dye laser is the first treatment choice for port-wine stains. However, as some facial port-wine stains are resistant to this modality, we evaluated the efficacy and safety of hematoporphyrin monomethyl ether (hemoporfin) photodynamic therapy for the treatment of such resistant port-wine stains.Methods: Patients were treated with two sessions of hemoporfin photodynamic therapy in our department. Patients received an intravenous injection of hematoporphyrin monomethyl ether (5 mg/kg) followed by 532 nm LED green light therapy. Three physicians graded the improvement in the port-wine stain, using a 4-level scale. Patients' satisfaction, reaction to treatment, and adverse effects were evaluated.Results: Thirty-one patients (mean age, 23.9 +/- 11.9 years, range, 3 -48 years) were enrolled in this study. Hypertrophic lesions accounted for 48.4% of port-wine stain, with 80.6% of lesions being larger than 40 cm(2). With regard to location, 41.9% were located on the central face and 32.3% involved a mix of the central and peripheral face. After one session, a treatment response was identified in 87.1% of cases, with the response deemed 'significant' in 29.0%. After two sessions, these rates increased to 100.0% and 61.3%, respectively. The clinical effect after two sessions was significantly greater than that after one session. Treatment reactions and adverse effects were well tolerated, and included pruritus, burning sensation, pain, edema, purpura-like change, blister, crust, and hyperpigmentation.Conclusions: Hemoporfin photodynamic therapy is a promising treatment for port-wine stains resistant to pulsed dye laser therapy.
机译：背景：脉冲染料激光器是蒲式葡萄酒污渍的第一个治疗选择。然而，随着一些面部斗葡萄酒污渍对这种方式进行抗性，我们评估了血液卟啉单甲基醚（血红液）光动力疗法治疗这种抗性葡萄酒污渍的疗效和安全性。方法：患者被两次休息治疗我们部门的血管赘光学动力学疗法。患者接受静脉注射血管卟啉单甲基醚（5mg / kg），然后进行532nm LED绿光疗法。三个医生使用4级规模渐变了斗葡萄酒污渍的改善。患者的满意度，治疗反应和评估不良反应。结果：三十一名患者（平均年龄，23.9 +/- 11.9岁，范围，3-48岁）在本研究中注册。肥厚病变占港葡萄酒污染的48.4％，80.6％的病变大于40厘米（2）。关于位置，41.9％位于中心面上，32.3％涉及中央和周边的混合。在一次会议之后，在87.1％的病例中确定了治疗反应，答复被认为是29.0％的“重要”。经过两次课程，这些率分别增加到100.0％和61.3％。两次会议后，临床效果明显大于一届会议后的临床效果。治疗反应和不良反应是良好的耐受性，包括瘙痒，灼热感，疼痛，水肿，紫癜状的变化，泡沫，地壳和高度沉降。结论：血管管素光动力疗法是抗脉冲染料的斗葡萄酒污渍的有希望的处理激光治疗。

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