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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Efficacy of photodynamic therapy for the treatment of Bowen's disease: An updated systematic review and meta-analysis of randomized controlled trials
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Efficacy of photodynamic therapy for the treatment of Bowen's disease: An updated systematic review and meta-analysis of randomized controlled trials

机译：光动力治疗对鲍文病治疗的疗效：随机对照试验的更新系统综述与荟萃分析

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Background: This is a systematic review and meta-analysis on the effectiveness of Photodynamic Therapy (PDT) in Bowen's Disease (BD), with further summary of the data from all randomized controlled trials (RCTs).Methods: Relevant data were extracted after conducting a literature search via PubMed, Embase, Scopus, the Cochrane Library, CNKI, and Wanfang databases, from inception until 31 July 2019. Meta-analyses of the data were performed using RevMan V.5.3. A total of 392 published RCTs related to the efficacy of PDT in BD treatment were identified. The papers were screened for duplicates and excluded based on title and abstract. Subsequently, 85 full-text articles were thoroughly reviewed and finally, data from 446 patients with 1147 skin lesions across 12 eligible studies were collated.Results: Our findings revealed significant differences between the efficacies of PDT and other treatments, where a higher lesion reduction rate was observed after the first treatment session following PDT (P 0.00001, Z = 4.98). PDT was found to be more effective than 5-fluorouracil (P 0.00001, Z = 4.42) and cryotherapy (P = 0.008, Z = 2.67). However, there were no significant differences in recurrence rates following treatments with PDT, cryotherapy, and 5-fluorouracil.Conclusions: This systematic review and meta-analysis confirms and collates data from all RCTs pertaining to the efficacy of PDT for BD treatment. Our study has reiterated that PDT is more effective than 5-fluorouracil and cryotherapy for the treatment of BD.
机译：背景：这是对鲍文疾病（BD）的光动力治疗（PDT）有效性的系统评价和荟萃分析，具有来自所有随机对照试验（RCT）的数据的进一步摘要。方法：在进行后提取相关数据通过PubMed，Embase，Scopus，Cochrane库，CNKI和Wanfang数据库的文献搜索，从成立到2019年7月31日。使用Revman V.5.3进行数据的Meta分析。确定了与BD治疗中PDT疗效相关的392名已发表的RCT。筛选纸张用于重复，并根据标题和摘要排除。随后，彻底审查了85条全文文章，最后，446例患有12项符号研究的1147名皮肤病患者的数据进行了综合评审。结果：我们的发现揭示了PDT和其他治疗的疗效之间的显着差异，其中病变降低率较高在PDT后第一次处理会议后观察到（P <0.00001，Z = 4.98）。发现PDT比5-氟尿嘧啶更有效（P <0.00001，Z = 4.42）和冷冻疗法（P = 0.008，Z = 2.67）。然而，在PDT，冷冻疗法和5-氟尿嘧啶治疗后复发率没有显着差异。结论：这种系统审查和荟萃分析证实并巩固了与PDT对BD治疗的疗效相关的所有RCT的数据。我们的研究重申，PDT比5氟尿嘧啶和冷冻疗法更有效，用于治疗BD。

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