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Treatment of infected wounds with methylene blue photodynamic therapy: An effective and safe treatment method

机译：用亚甲基蓝色光动力疗法治疗感染伤口：一种有效和安全的处理方法

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摘要

Background: Bacterial resistance is a problem during the process of healing of infected wounds. As a therapy, photodynamic therapy (PDT) has broad-spectral antibacterial activity and non-selective action, which makes it possible to deal with antibiotic resistance.. Methylene blue is a commonly used medicine, but it is rarely used in clinical practice as a photosensitizer. The effect of methylene blue photodynamic therapy (MB-PDT) on infected wounds remains unclear. Our study aims to evaluate the safety and efficacy of MB-PDT on infected wounds.Methods: In this study, 5 patients with infected wounds were included, all of them were treated with MB-PDT by using the red LED which irradiated the wounds directly (635 nm, 120 J/cm2, 100 mW/cm2). The frequency and course of treatment were determined by the severity of the wound.Results: After an average of 4 PDT session, infected wounds of all the patients healed.. The treatment also showed an excellent cosmetic effect. According to the follow-up periods of patients ranged from 3 to 12 months, there were no recurrences and side effects.Conclusions: MB-PDT has a great healing effect on infected wounds, and it is a safe, cheap and active clinical therapy.
机译：背景：细菌抗性是在感染伤口愈合过程中的问题。作为治疗，光动力治疗（PDT）具有广泛的抗菌活性和非选择性作用，这使得可以处理抗生素抗性。亚甲基蓝色是常用的药物，但它很少用于临床实践中的临床实践光敏剂。亚甲基蓝色光动力治疗（MB-PDT）对感染伤口的影响仍不清楚。我们的研究旨在评估MB-PDT对感染的伤口的安全性和功效。在本研究中，包括5名受感染伤口的患者，所有这些患者用MB-PDT处理，使用红色LED直接照射伤口的红色LED （635nm，120 j / cm2,100 mw / cm2）。治疗的频率和疗程由伤口的严重程度决定。结果：在平均4个PDT会议后，所有患者的感染伤口都愈合了。治疗也显示出优异的化妆品效果。根据3至12个月的患者的后续期间，没有复发和副作用。结论：MB-PDT对感染的伤口具有很大的愈合效果，并且是一种安全，便宜和活跃的临床治疗。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2020年第12期|102051.1-102051.4|共4页
  • 作者

    Shen Xiaoxiao; Dong Liwen; He Xuan; Zhao Chuanqi; Zhang Wanqi; Li Xinying; Lu Yuangang;

  • 作者单位

    Amy Med Univ Daping Hosp Dept Plast & Cosmet Surg Chongqing 400042 Peoples R China;

    Amy Med Univ Daping Hosp Dept Plast & Cosmet Surg Chongqing 400042 Peoples R China;

    Amy Med Univ Daping Hosp Dept Plast & Cosmet Surg Chongqing 400042 Peoples R China;

    Amy Med Univ Daping Hosp Dept Plast & Cosmet Surg Chongqing 400042 Peoples R China;

    Amy Med Univ Daping Hosp Dept Plast & Cosmet Surg Chongqing 400042 Peoples R China;

    Amy Med Univ Daping Hosp Dept Plast & Cosmet Surg Chongqing 400042 Peoples R China;

    Amy Med Univ Daping Hosp Dept Plast & Cosmet Surg Chongqing 400042 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Photodynamic therapy; Methylene blue; Infected wounds;

    机译：光动力疗法;亚甲基蓝色;感染伤口;

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