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首页> 外文期刊>Polar biology >Cdna Microarray Analysis Reveals The Capacityof The Cold-adapted Antarctic Fish Trematomus Bernacchii to Alter Gene Expression In Response To Heat Stress
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Cdna Microarray Analysis Reveals The Capacityof The Cold-adapted Antarctic Fish Trematomus Bernacchii to Alter Gene Expression In Response To Heat Stress

机译：Cdna芯片分析揭示了冷适应的南极鱼类Tematomus Bernacchii响应热应激改变基因表达的能力

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摘要

During their many millions of years of evolution in the extreme and stable cold, Antarctic notothenioid fishes have acquired profoundly cold-adapted physiologies. Gene expression profiling via cDNA microarray was used to determine the extent to which one species of notothenioid, Trematomus bernacchii, has retained the ability to alter gene expression in response to heat stress. While an inability to up-regulate the expression of any size class of heat shock proteins (except for a 1.1-fold induction of the co-chaperone Hsp40) was observed, hundreds of additional genes, associated with a broad range of cellular processes, were responsive to heat. Many of these genes are associated with central aspects of the evolutionarily conserved cellular stress response (CSR), which plays a pivotal role in responding to physical and chemical stresses. The inability of T. bernacchii to mount a heat shock response underscores the potential susceptibility of this species to the effects of global warming.
机译：在极端和稳定的寒冷环境中经过数百万年的进化，南极类胡萝卜素鱼类已获得了深深适应寒冷的生理学。通过cDNA微阵列进行基因表达谱分析，可确定一种类胡萝卜素类药物伯纳木霉（Trematomus bernacchii）保留了响应热应激而改变基因表达的能力的程度。尽管观察到不能上调任何大小类别的热休克蛋白的表达（除了对陪伴分子Hsp40的1.1倍诱导），还发现了数百种与广泛的细胞过程相关的其他基因。对热敏感。这些基因中的许多与进化保守的细胞应激反应（CSR）的中心方面有关，CSR在响应物理和化学应激中起关键作用。伯纳河杆菌无法进行热激反应，突显了该物种对全球变暖的潜在敏感性。

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