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首页> 外文期刊>Polymer Degradation and Stability >Degradation behavior of poly(lactide-co-glycolide)/β-TCP composites prepared using microwave energy
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Degradation behavior of poly(lactide-co-glycolide)/β-TCP composites prepared using microwave energy

机译：微波能制备的丙交酯-乙交酯/β-TCP复合材料的降解行为

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摘要

Biodegradable poly(lactide-co-glycolide) (PLGA)/β-tricalcium phosphate (P-TCP) composites were synthesized through polymerization using microwave energy. The degradation behavior of the PLGA/ β-TCP composites was carried out at 37 ℃ in a SBF without changing the solution in order to examine the effect of β-TCP on the degradation behavior. The changes in the molecular weight, mass, and morphology of the composites were examined with respect to the soaking time. An incubation time of 2 weeks was needed to degrade the β-TCP of the composites, indicating that degradation of β-TCP could be started when β-TCP was detached from the PLGA matrix or exposed from composites surface, caused by PLGA matrix was degraded into the SBF solution. The mass loss of the composites with respect to the soaking time revealed that PLGA transformed from a polymer to an oligomer as the degradation process proceeded. The whisker-like morphological changes, caused by the transformation and degradation of the polymer were observed in the composites after week 2. The degradation behavior of the PLGA/β-TCP composites was influenced by the β-TCP content in the composite, and the degradation rate of the composite could be controlled by the initial molecular weight of PLGA.
机译：通过微波能量的聚合反应合成了可生物降解的丙交酯-乙交酯共聚物（PLGA）/β-磷酸三钙（P-TCP）复合材料。为了检测β-TCP对降解行为的影响，在不改变溶液的情况下，于37℃在SBF中进行了PLGA /β-TCP复合材料的降解行为。就浸泡时间而言，检查了复合材料的分子量，质量和形态的变化。需要2周的孵育时间以降解复合材料的β-TCP，这表明当由PLGA基质降解导致β-TCP脱离PLGA基质或从复合材料表面暴露时，β-TCP可以开始降解。进入SBF解决方案。复合材料相对于浸泡时间的质量损失表明，随着降解过程的进行，PLGA从聚合物转变为低聚物。在第2周后，在复合材料中观察到了由聚合物的转变和降解引起的晶须状形态变化。PLGA /β-TCP复合材料的降解行为受到复合材料中β-TCP含量的影响，并且复合材料的降解速率可以通过PLGA的初始分子量来控制。

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  • 来源
    《Polymer Degradation and Stability》 |2010年第9期|p.1856-1861|共6页
  • 作者

    Hyeong-Ho Jin; rnSang-Ho Min; rnYong-Keun Song; rnHong-Chae Park; rnSeog-Young Yoon;

  • 作者单位

    School of Materials Science and Engineering, Pusan National University, San 30, Jangjeon-dong, Gumjeong-gu, Busan 609-735, South Korea;

    rnSchool of Materials Science and Engineering, Pusan National University, San 30, Jangjeon-dong, Gumjeong-gu, Busan 609-735, South Korea;

    rnSchool of Materials Science and Engineering, Pusan National University, San 30, Jangjeon-dong, Gumjeong-gu, Busan 609-735, South Korea;

    rnSchool of Materials Science and Engineering, Pusan National University, San 30, Jangjeon-dong, Gumjeong-gu, Busan 609-735, South Korea;

    rnSchool of Materials Science and Engineering, Pusan National University, San 30, Jangjeon-dong, Gumjeong-gu, Busan 609-735, South Korea;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    in vitro; biodegradable; PLGA; β-TCP; microwave;

    机译：体外;可生物降解PLGA;β-TCP;微波;

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