• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of American Thoracic Society >Decreased Distribution of Airway Lymphatics in Individuals with Fatal Asthma
【24h】

Decreased Distribution of Airway Lymphatics in Individuals with Fatal Asthma

机译：致命性哮喘患者气道淋巴管分布减少

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

I previously reported the phenotypic distribution patterns of airway smooth muscles in individuals with fatal asthma (individuals with Type I asthma with smooth muscle bundle thickening only in large airways and Type II in whole airways), in comparison with normal control lungs, by different mechanisms of airway smooth muscles, hypertrophy, and/or hyperplasia (Am Rev Respir Dis 1990;141:1322,1327, and 1993; 148:720). We hypothesized that increased smooth muscle bundles in the airway walls would disrupt airway lymphatics to impair airway clearance in these individuals with fatal asthma. Methods: The autopsy lungs of seven individuals with fatal asthma (three with Type I, four with Type II asthma) and five control subjects were examined by immunohistochemistry to reveal the lymphatics distributed in the airway walls. The total area of lymphatics around each cross-sectioned airway was measured and its airway radius was calculated using an image analyzer system. Results: The total area of airway lymphatics in each lung was found to be positively correlated with the airway radius (R). The distribution areas of lymphatics in larger airways of individuals with both types of asthma were significantly decreased compared with those of control subjects, and individuals with Type I asthma contained much less lymphatics in these airways than did individuals with Type II asthma. The
机译：我以前曾报道过致命性哮喘患者（个体I型哮喘，其平滑肌束增厚仅在大气道中，而II型在整个气道中）的表型分布模式，与正常对照肺相比，通过不同的机制气道平滑肌，肥大和/或增生（Am Rev Respir Dis 1990; 141：1322、1327和1993; 148：720）。我们假设气道壁平滑肌束增加会破坏这些致命性哮喘患者的气道淋巴管，损害其气道通畅性。方法：采用免疫组织化学方法对7例致命性哮喘患者（3例I型哮喘，4例II型哮喘）的尸检肺进行免疫组织化学检查，以发现淋巴管分布在气道壁中。测量每个横截面气道周围的淋巴管的总面积，并使用图像分析仪系统计算其气道半径。结果：发现每个肺中的气道淋巴管的总面积与气道半径（R）正相关。与对照组相比，两种哮喘类型的个体在较大气道中的淋巴管分布区域均明显减少，并且与II型哮喘患者相比，I型哮喘患者在这些气道中淋巴管的分布少得多。的

著录项

  • 来源
    《Proceedings of American Thoracic Society》 |2009年第3期|p.327|共1页
  • 作者

    Masahito Ebina;

  • 作者单位

    Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号