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首页> 外文期刊>Proceedings of the Institution of Mechanical Engineers. Part L, Journal of Materials: Design and Application >Mechanical degradation model of porous magnesium scaffolds under dynamic immersion
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Mechanical degradation model of porous magnesium scaffolds under dynamic immersion

机译：动态浸没条件下多孔镁支架的机械降解模型

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摘要

A new generation of bone scaffolds incorporates features like biodegradability and biocompatibility. A combination of these attributes will result in having a temporary bone scaffold for tissue regeneration that mimics the natural cancellous bone. Under normal conditions, scaffolds will be gradually eroded. This surface erosion occurs due to the immersion and the movement of bone marrow. Surface erosion on bone scaffolds leads to changes of the morphology. The mechanical response of the scaffolds due to the surface erosion is not fully understood. The aim of this study is to assess the influence of the dynamic immersion condition on the degradation behaviour and mechanical properties of porous magnesium. In the present work, load-bearing biomaterial scaffolds made of pure magnesium are immersed in simulated body fluids (SBF) with a certain flow rate. Samples with different porosities are subjected to tomography and are used to develop virtual 3D models. By means of numerical simulations, the mechanical properties, for instance, elastic modulus, plateau stress, 0.2% offset yield stress and energy absorption of these degraded samples are collected. The findings are then validated with the values obtained from the experimental tests. Finite element method enables the study on the failure mechanism within the biomaterial scaffolds. The knowledge of how weak walls or thin struts collapsed under compressive loading is essential for future biomaterial scaffolds development. Results from the experimental tests are found in sound good agreement with the numerical simulations.
机译：新一代的骨支架具有生物降解性和生物相容性等功能。这些属性的组合将导致具有用于模仿天然松质骨的组织再生的临时骨支架。在正常情况下，脚手架将逐渐被侵蚀。这种表面腐蚀是由于骨髓的浸入和运动而发生的。骨支架上的表面侵蚀导致形态变化。由于表面侵蚀而导致的支架的机械响应尚未完全了解。这项研究的目的是评估动态浸没条件对多孔镁的降解行为和力学性能的影响。在当前的工作中，将纯镁制成的承重生物材料支架以一定的流速浸入模拟体液（SBF）中。对具有不同孔隙率的样品进行断层扫描，并用于开发虚拟3D模型。通过数值模拟，收集了这些降解样品的机械性能，例如弹性模量，平稳应力，0.2％偏移屈服应力和能量吸收。然后将这些结果与从实验测试中获得的值进行验证。有限元方法可以研究生物材料支架内的失效机理。关于薄壁或薄支柱在压缩载荷下如何塌陷的知识对于未来生物材料支架的开发至关重要。实验测试的结果与数值模拟完全吻合。

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