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首页> 外文期刊>Proceedings of the institution of mechanical engineers >Use of 2% hydroxypropyl methylcellulose to prevent the corneal swelling during the in vitro mechanical characterization
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Use of 2% hydroxypropyl methylcellulose to prevent the corneal swelling during the in vitro mechanical characterization

机译：使用2％羟丙基甲基纤维素以防止在体外机械表征期间的角膜肿胀

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The aim of this study was to assess the use of 2% HPMC during in vitro uniaxial tensile tests, with corneal strips immediately obtained or after storing the eyes for 24 h in 0.9% NaCl solution at 4 celcius. The purpose was to establish a standardized procedure to prevent phenomena which can modify the mechanical properties of the tissue. Rabbit eyes were divided into four groups. Group A had seven eyes that were preserved in NaCl solution for 24 h before testing. Group B had seven eyes that were immediately tested. In both groups, to prevent both swelling and dehydration, 2% hydroxypropyl methylcellulose (2% HPMC) was applied. Group C had seven eyes that were preserved in NaCl solution for 24 h before testing. Group D had seven eyes that were immediately tested. In both groups, HPMC was not applied. Regarding the mechanical response, groups with HPMC showed similar Cauchy stress-stretch curves and there were no statistically significant differences at 5%, 10% and 15% strain between them, which mean that both showed similar mechanical behavior. The same result was obtained between groups without HPMC. However, for coupled groups with and without HPMC, statistically significant differences at 10% and 15% strain were observed. On the other hand, when grouped by storage time, statistically significant differences were found between groups that had eyes preserved for 24 h with and without HPMC, respectively, as well as between groups immediately tested with and without HPMC, respectively, at 15% strain. Nevertheless, if coupled groups were considered, between groups that were preserved for 24 h in NaCl before testing and groups that were immediately tested, no statistically significant differences were obtained. In addition, the Cauchy stress-stretch curves of groups without HPMC showed a decreasing slope of the linear part (strain 8%) of the graph during the experiment. In summary, the use of HPMC during the handling of the tissue from excision to testing seems to prevent both swelling and dehydration.
机译：本研究的目的是在体外的单轴拉伸试验期间评估2％HPMC的使用，立即获得角膜条或在4个Celcius在0.9％NaCl溶液中储存24小时后的角膜条。目的是建立标准化程序，以防止能够改变组织的机械性能的现象。兔眼分为四组。 A组有七只眼睛，在测试前在NaCl溶液中保存24小时。 B组有七只眼睛立即测试。在两组中，为了防止溶胀和脱水，施加2％羟丙基甲基纤维素（2％HPMC）。 C组在测试之前，在NaCl溶液中保存了七只眼睛。 D组有七只眼睛立即测试。在这两个群体中，氟氯烃淘汰管理委员会未申请。关于机械响应，具有HPMC的基团显示出类似的Cauchy应激拉伸曲线，它们之间没有统计学上显着的差异在它们之间的5％，10％和15％的菌株中，这意味着两者都显示出类似的机械行为。在没有HPMC的基团之间获得相同的结果。然而，对于具有和不具有HPMC的偶联基团，观察到10％和15％菌株的统计学上显着差异。另一方面，当通过储存时间进行分组时，在统计上存在显着的差异，分别在患有24小时和不具有HPMC的组中，以及在15％菌株中分别在和没有HPMC测试的基团之间。然而，如果考虑偶联基团，在测试和立即测试的组在NaCl中保留24小时的组之间，则没有获得统计学上显着的差异。另外，在实验期间，没有HPMC的组的Cauchy应激拉伸曲线显示了图形的线性部分（菌株> 8％）的降低。总之，在从切除切除测试期间使用HPMC似乎防止肿胀和脱水。

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