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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice.
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Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice.

机译:Hoxd-11突变小鼠的轴骨骼顺势和前肢畸形。

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摘要

The Hoxd-11 gene was disrupted by homologous recombination in embryonic stem cells. We found that Hoxd-11-/- mutant mice are viable and display homeotic transformations of their sacral vertebrae, while their forelimbs present abnormalities of some metacarpals and of the first row of carpal bones. These results are discussed in the light of current models of tetrapod axial skeleton and limb patterning.
机译:Hoxd-11基因被胚胎干细胞中的同源重组破坏。我们发现Hoxd-11-/-突变小鼠是可行的,并且显示出s骨椎骨的同种异体转化,而它们的前肢则表现出一些掌骨和腕骨第一排的异常。根据四脚架轴向骨骼和肢体模式的当前模型讨论了这些结果。

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