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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >T cells with two functional antigen-specific receptors.
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T cells with two functional antigen-specific receptors.

机译：具有两个功能性抗原特异性受体的T细胞。

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摘要

Although the clonal selection theory states that lymphocytes should bear only a single specificity of receptor, there is much evidence that some T cells, at least, bear two receptors. Here, we have used mice transgenic for genes encoding an autoreactive T-cell receptor (TCR) to examine the specificity of T cells bearing two functional TCRs. We find that T cells developing in mice that do not express the major histocompatibility complex (MHC) molecule recognized as self by the transgene-encoded TCR express both this TCR and a second TCR that is specific for the MHC molecules of the strain in which it arose. Thus, these T cells have two TCRs, each specific for a distinct antigen bound to a distinct MHC molecule. In contrast, when raised in mice bearing the MHC for which the receptor is specific, T cells develop that express the transgene-encoded TCR almost exclusively. Such mice are highly susceptible to autoimmune disease. Our data suggest that on most T cells bearing two TCRs, only one is specific for peptides bound to self-MHC molecules and, thus, that expression of two TCRs does not usually confer reactivity to two unrelated antigens.
机译：尽管克隆选择理论指出淋巴细胞应仅具有单一的受体特异性，但有许多证据表明某些T细胞至少具有两个受体。在这里，我们使用了转基因小鼠来编码自身反应性T细胞受体（TCR）的基因，以检查带有两个功能性TCR的T细胞的特异性。我们发现，在不表达被转基因编码的TCR识别为自身的主要组织相容性复合物（MHC）分子的小鼠中发育的T细胞表达了该TCR和第二种TCR，该第二种TCR对该菌株的MHC分子具有特异性出现了。因此，这些T细胞具有两个TCR，每个对与不同的MHC分子结合的不同抗原具有特异性。相反，当在带有受体特异性MHC的小鼠中长大时，T细胞会发育，几乎只表达转基因编码的TCR。这样的小鼠高度易患自身免疫疾病。我们的数据表明，在大多数带有两个TCR的T细胞上，只有一个特异于与自身MHC分子结合的肽，因此，两个TCR的表达通常不会赋予与两种不相关抗原的反应性。

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