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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster.
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The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster.

机译:周期时钟基因在中枢神经系统神经元中表达,中枢神经系统神经元也产生一种神经肽,可揭示果蝇大脑内昼夜节律性起搏器细胞的投射。

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摘要

The period protein (PER) is a essential component of the circadian clock in Drosophila melanogaster. Although PER-containing pacemaker cells have been previously identified in the brain, the neuronal network that comprises the circadian clock remained unknown. Here it is shown that some PER neurons are also immunostained with an antiserum against the crustacean pigment-dispersing hormone (PDH). This antiserum reveals the entire arborization pattern of these pacemaker cells. The arborizations of these neurons are appropriate for modulation of the activity of many neurons and they might interact with PER-containing glial cells. A putative physiological role of PDH in the circadian system is discussed.
机译:周期蛋白(PER)是果蝇中昼夜节律的重要组成部分。尽管先前已在大脑中鉴定出含PER的起搏器细胞,但仍不知道组成生物钟的神经元网络。此处显示,一些PER神经元也被抗甲壳动物色素分散激素(PDH)的抗血清免疫染色。该抗血清揭示了这些起搏器细胞的整个乔化模式。这些神经元的乔化适合于调节许多神经元的活性,它们可能与含PER的神经胶质细胞相互作用。讨论了PDH在昼夜节律系统中的假定生理作用。

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