Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor.

Kamohara S; Hayashi H; Todaka M; Kanai F; Ishii K; Imanaka T; Escobedo JA; Williams LT; Ebina Y

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Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor.

机译：血小板衍生的生长因子主要通过受体上的磷脂酰肌醇3激酶结合位点触发胰岛素调节的葡萄糖转运蛋白（4型）的转运。

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Insulin is the only known hormone which rapidly stimulates glucose uptake in target tissues, mainly by translocation to the cell surface of the intracellular insulin-regulatable glucose transporter (glucose transporter type 4, GLUT4). We have developed a cell line for direct, sensitive detection of GLUT4 on the cell surface. We have suggested that insulin-activated phosphatidylinositol (PI) 3-kinase may be involved in the signaling pathway of insulin-stimulated GLUT4 translocation. We report that platelet-derived growth factor (PDGF), which stimulates PI 3-kinase activity, triggers GLUT4 translocation in Chinese hamster ovary (CHO) cells stably overexpressing the PDGF receptor and in 3T3-L1 mouse adipocytes. Using mutant PDGF receptors that cannot bind to Ras-GTPase-activating protein, phospholipase C-gamma, and PI 3-kinase, respectively, we obtained evidence that PI 3-kinase binding sites play a key role in the signaling pathway of PDGF-stimulated GLUT4 translocation in the CHO cell system.

机译：胰岛素是唯一已知的激素，其主要通过易位至细胞内胰岛素调节性葡萄糖转运蛋白（4型葡萄糖转运蛋白GLUT4）的细胞表面而迅速刺激靶组织中的葡萄糖吸收。我们已经开发出一种细胞系，用于直接，灵敏地检测细胞表面的GLUT4。我们建议胰岛素激活的磷脂酰肌醇（PI）3-激酶可能参与胰岛素刺激的GLUT4易位的信号通路。我们报道血小板源性生长因子（PDGF），刺激PI 3-激酶活性，触发中国仓鼠卵巢（CHO）细胞稳定过表达PDGF受体和3T3-L1小鼠脂肪细胞中的GLUT4易位。我们分别使用不能与Ras-GTPase激活蛋白，磷脂酶C-γ和PI 3-激酶结合的突变PDGF受体，获得了PI 3-激酶结合位点在PDGF刺激的信号通路中起关键作用的证据。 CHO细胞系统中的GLUT4易位。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第4期|P.1077-1081|共5页
作者
Kamohara S; Hayashi H; Todaka M; Kanai F; Ishii K; Imanaka T; Escobedo JA; Williams LT; Ebina Y;
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作者单位

Department of Enzyme Genetics, University of Tokushima, Japan.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Insulin; Monosaccharide Transport Proteins; Phosphotransferases Alcohol Group Acceptor metabolism; 胰岛素; 单糖转运蛋白质类; 血小板源生长因子; 受体; 血小板源生长因子;

机译：Insulin;Monosaccharide Transport Proteins;Phosphotransferases Alcohol Group Acceptor metabolism;胰岛素;单糖转运蛋白质类;血小板源生长因子;受体;血小板源生长因子;

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专利

1. The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor. [J] . A Klippel, J A Escobedo, W J Fantl, Molecular and Cellular Biology . 1992,第4期

机译：p85的C末端SH2结构域说明了磷脂酰肌醇3-激酶与磷酸化血小板衍生的生长因子β受体结合的高亲和力和特异性。
2. Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor ( EGFR)-mutated Lung Adenocarcinoma * [J] . Hideki Makinoshima, Masahiro Takita, Koichi Saruwatari, The Journal of biological chemistry . 2015,第28期

机译：通过磷脂酰肌醇3-激酶（PI3K）/哺乳动物的雷帕霉素（MTOR）轴的信号负责由表皮生长因子受体中葡萄糖转运蛋白介导的有氧糖醇（<斜斜体> EGFR ） - 突变肺腺癌 *
3. A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor. [J] . C Ponzetto, A Bardelli, F Maina, Molecular and Cellular Biology . 1993,第8期

机译：磷脂酰肌醇3-激酶结合的新型识别基序介导其与肝细胞生长因子/散射因子受体的关联。
4. Toxicity Study of Recombinant Human Platelet-Derived Growth Factor-BB Hydrated Bovine Type I Collagen in Decorated Femur Model in Rabbits—a Safety Study Model for Rotator Cuff Repair [C] . YanchunLiu, Jack Ratliff, Vivek Shah, Annual meeting of the Society for Biomaterials . 2011

机译：重组人血小板衍生生长因子-BB水合牛I型胶原在家兔股骨装饰模型中的毒性研究—肩袖修复的安全性研究模型
5. Interactions between the guanine nucleotide exchange factor, vav2, the platelet-derived growth factor receptor-beta and phosphoinositide 3-kinase in coronary artery vascular smooth muscle cells: Functional implications in atherosclerosis. [D] . Cushman-Vokoun, Allison Marie. 2002

机译：鸟嘌呤核苷酸交换因子，vav2，血小板衍生的生长因子受体-β和磷酸肌醇3激酶在冠状动脉血管平滑肌细胞中的相互作用：在动脉粥样硬化中的功能含义。
6. Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor. [O] . S Kamohara, H Hayashi, M Todaka, 1995

机译：血小板衍生的生长因子主要通过受体上的磷脂酰肌醇3-激酶结合位点触发胰岛素调节的葡萄糖转运蛋白（4型）的转运。
7. Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor. [O] . Kamohara, S, Hayashi, H, Todaka, M, 1995

机译：血小板衍生的生长因子主要通过受体上的磷脂酰肌醇3-激酶结合位点触发胰岛素调节的葡萄糖转运蛋白（4型）的转运。

Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor.

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