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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Inflammatory mediators increase surface expression of integrin ligands, adhesion to lymphocytes, and secretion of interleukin 6 in mouse Sertoli cells.
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Inflammatory mediators increase surface expression of integrin ligands, adhesion to lymphocytes, and secretion of interleukin 6 in mouse Sertoli cells.

机译：炎性介质增加了小鼠支持细胞中整联蛋白配体的表面表达，对淋巴细胞的粘附以及白介素6的分泌。

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摘要

The expression of the cell adhesion molecules ICAM-1, ICAM-2, and VCAM-1 and the secretion of the cytokine interleukin 6 have been measured in mouse Sertoli cells cultured in vitro. Cytometric analysis revealed that, in basal conditions, low levels of ICAM-1 and VCAM-1 were present on the surface of the cells, whereas treatment with interleukin 1, tumor necrosis factor alpha, lipopolysaccharide, or interferon gamma induced, with different kinetics, increases in their expression. ICAM-2 was not detectable in basal conditions, nor was it inducible. Electron microscopic analysis and binding experiments using 51Cr-labeled lymphocytes demonstrated that increased expression of ICAM-1 and VCAM-1 on the surface of Sertoli cells, induced by inflammatory mediators, determines an augmented adhesion between the two cell types. The same stimuli, with the exception of interferon gamma, produced a rapid and remarkable increment of interleukin 6 production by Sertoli cells. These results suggest the presence of both direct and paracrine mechanisms of interaction between Sertoli and immune-competent cells, possibly involved in the control of immune reactions in the testis. Such mechanisms are of interest for the understanding of autoimmune pathologies of the testis and, if confirmed in humans, they could be involved in the sexual transmission of human immunodeficiency virus infection.
机译：已经在体外培养的小鼠支持细胞中测量了细胞粘附分子ICAM-1，ICAM-2和VCAM-1的表达以及细胞因子白介素6的分泌。细胞计数分析表明，在基础条件下，细胞表面存在低水平的ICAM-1和VCAM-1，而白介素1，肿瘤坏死因子α，脂多糖或干扰素γ诱导的治疗则具有不同的动力学，他们表达的增加。在基础条件下无法检测到ICAM-2，也无法诱导。使用51Cr标记的淋巴细胞进行的电子显微镜分析和结合实验表明，炎症介质诱导的Sertoli细胞表面ICAM-1和VCAM-1的表达增加，决定了这两种细胞类型之间粘附性的增强。除干扰素γ外，相同的刺激使Sertoli细胞的白介素6产生迅速而显着增加。这些结果表明Sertoli和免疫功能细胞之间存在直接和旁分泌相互作用的机制，可能参与了睾丸免疫反应的控制。这样的机制对于理解睾丸自身免疫病理是令人感兴趣的，并且如果在人类中得到证实，它们可能参与人类免疫缺陷病毒感染的性传播。

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