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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >FUNCTIONAL ANATOMY OF HUMAN EYEBLINK CONDITIONING DETERMINED WITH REGIONAL CEREBRAL GLUCOSE METABOLISM AND POSITRON-EMISSION TOMOGRAPHY
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FUNCTIONAL ANATOMY OF HUMAN EYEBLINK CONDITIONING DETERMINED WITH REGIONAL CEREBRAL GLUCOSE METABOLISM AND POSITRON-EMISSION TOMOGRAPHY

机译：用区域脑葡萄糖代谢和正电子发射断层照相术测定的人眼环境的功能解剖

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摘要

Relative cerebral glucose metabolism was examined with positron-emission tomography (PET) as a measure of neuronal activation during performance of the classically conditioned eyeblink response in 12 young adult subjects. Each subject received three sessions: (i) a control session with PET scan in which unpaired presentations of the tone conditioned stimulus and corneal airpuff unconditioned stimulus were administered, (ii) a paired training session to allow associative learning to occur, and (iii) a paired test session with PET scan, Brain regions exhibiting learning-related activation were identified as those areas that showed significant differences in glucose metabolism between the unpaired control condition and well-trained state in the 9 subjects who met the learning criterion, Areas showing significant activation included bilateral sites in the inferior cerebellar cortex/deep nuclei, anterior cerebellar vermis, contralateral cerebellar cortex and pontine tegmentum, ipsilateral inferior thalamus/red nucleus, ipsilateral hippocampal formation, ipsilateral lateral temporal cortex, and bilateral ventral striatum, Among all subjects, including those who did not meet the learning criterion, metabolic changes in ipsilateral cerebellar nuclei, bilateral cerebellar cortex, anterior vermis, contralateral pontine tegmentum, ipsilateral hippocampal formation, and bilateral striatum correlated with degree of learning, The localization to cerebellum and its associated brainstem circuitry is consistent with neurobiological studies in the rabbit model of eyeblink classical conditioning and neuropsychological studies in brain-damaged humans, In addition, these data support a role for the hippocampus in conditioning and suggest that the ventral striatum may also be involved. [References: 50]
机译：用正电子发射断层扫描（PET）检查了相对的大脑葡萄糖代谢情况，以此作为在12位年轻成人受试者中进行经典条件性眨眼反应期间神经元激活的量度。每个受试者接受三节训练：（i）通过PET扫描进行的对照训练，在该训练中进行了无条件的音调条件刺激和角膜气喘无条件刺激的表现，（ii）配对训练过程以允许进行联想学习，以及（iii）在与PET扫描配对的测试阶段中，表现出与学习相关的激活的大脑区域被确定为在满足学习标准的9位受试者中，未配对的对照条件和训练有素的状态之间显示出葡萄糖代谢显着差异的区域，激活包括下小脑皮质/深核的双侧部位，小脑前部的mis骨，对侧小脑皮质和桥脑小盖，同侧下丘脑/红色核，同侧海马形成，同侧外侧颞皮层以及双侧腹侧纹状体，那些不符合学习标准的人，代谢与学习程度相关的同侧小脑核，双侧小脑皮层，前ver，对侧桥状脑膜，同侧海马形成和双侧纹状体中垂悬着。小脑及其相关脑干回路的定位与兔眼闪烁模型中的神经生物学研究一致此外，这些数据支持了海马在调节中的作用，并暗示腹侧纹状体也可能参与其中。 [参考：50]

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