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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >LYMPHOCYTES SELECTED IN ALLOGENEIC THYMIC EPITHELIUM MEDIATE DOMINANT TOLERANCE TOWARD TISSUE GRAFTS OF THE THYMIC EPITHELIUM HAPLOTYPE
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LYMPHOCYTES SELECTED IN ALLOGENEIC THYMIC EPITHELIUM MEDIATE DOMINANT TOLERANCE TOWARD TISSUE GRAFTS OF THE THYMIC EPITHELIUM HAPLOTYPE

机译：异种胸腺上皮的淋巴细胞选择对胸腺上皮型组织移植物的显性耐受

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摘要

Athymic mice grafted at birth with allogeneic thymic epithelium (TE) from day 10 embryos before hematopoietic cell colonization reconstitute normal numbers of T cells and exhibit full life-long tolerance to skin grafts of the TE haplotype. Intravenous transfers of splenic cells, from these animals to adult syngeneic athymic recipients, reconstitute T-cell compartments and the ability to reject third-party skin grafts. The transfer of specific tolerance to skin grafts of the TE donor strain, however, is not observed in all reconstituted recipients, and the fraction of nontolerant recipients increases with decreasing numbers of cells transferred. Furthermore, transfers of high numbers of total or CD4(+) T cells from TE chimeras to T-cell receptor-anti-H-Y antigen transgenic immunocompetent syngeneic hosts specifically hinder the rejection of skin grafts of the TE haplotype that normally occurs in such recipients. These observations demonstrate (i) that mice tolerized by allogeneic TE and bearing healthy skin grafts harbor peripheral immunocompetent T cells capable of rejecting this very same graft; and (ii) that TE selects for regulatory T cells that can inhibit effector activities of graft-reactive cells. [References: 65]
机译：造血细胞定殖前，从出生第10天起就移植了异基因胸腺上皮（TE）的无胸腺小鼠重组了正常数量的T细胞，并表现出对TE单倍型皮肤移植物的终生耐受性。脾脏细胞从这些动物到成年同基因无胸腺受者的静脉内转移，重构了T细胞区室，并具有排斥第三方皮肤移植物的能力。然而，在所有重构的受体中均未观察到特异耐受性向TE供体菌株的皮肤移植物的转移，并且非耐受性受体的比例随转移细胞数量的减少而增加。此外，大量的总T细胞或CD4（+）T细胞从TE嵌合体转移到T细胞受体-抗H-Y抗原转基因免疫能力同源宿主中，这特别阻碍了通常在这类受体中发生的TE单倍型皮肤移植物的排斥。这些观察结果表明：（i）同种异体TE耐受并带有健康皮肤移植物的小鼠具有能够排斥该相同移植物的外周免疫功能T细胞； （ii）TE选择可以抑制移植物反应性细胞的效应子活性的调节性T细胞。 [参考：65]

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