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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >ANIMAL MODEL FOR THE THERAPY OF ACQUIRED IMMUNODEFICIENCY SYNDROME WITH REVERSE TRANSCRIPTASE INHIBITORS
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ANIMAL MODEL FOR THE THERAPY OF ACQUIRED IMMUNODEFICIENCY SYNDROME WITH REVERSE TRANSCRIPTASE INHIBITORS

机译：逆转录酶抑制剂治疗获得性免疫缺陷综合症的动物模型

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摘要

The reverse transcriptase (RT) of the human immunodeficiency virus type 1 (HIV-1) is the major target for antiretroviral therapy of the acquired immunodeficiency syndrome (AIDS), While some inhibitors exhibit activity against most retroviral RTs, others are specific for the HIV-1 enzyme. To develop an animal model for the therapy of the HIV-1 infection with RT inhibitors, the RT of the simian immuno-deficiency virus (SIV) was replaced by the RT of HIV-1. Macaques infected with this SIV/HIV-1 hybrid virus developed AIDS-like symptoms and pathology, The HIV-1-specific RT inhibitor LY300046 . HCl, but not zidovudine [3'-azido-3'deoxythymidine (AZT)] delayed the appearance of plasma antigenemia in macaques infected with a high dose of the chimeric virus, Infection of macaques with the chimeric virus seems to be a valuable model to study the in vivo efficacy of new RT inhibitors, the emergence and reversal of drug resistance, the therapy of infections with drug-resistant viruses, and the efficacy of combination therapy. [References: 38]
机译：人类免疫缺陷病毒1型（HIV-1）的逆转录酶（RT）是获得性免疫缺陷综合症（AIDS）的抗逆转录病毒疗法的主要靶标，尽管某些抑制剂对大多数逆转录病毒RT表现出活性，但其他抑制剂对HIV具有特异性-1酶。为了开发一种用RT抑制剂治疗HIV-1感染的动物模型，将猿猴免疫缺陷病毒（SIV）的RT替换为HIV-1的RT。感染了这种SIV / HIV-1混合病毒的猕猴出现了类似AIDS的症状和病理，即HIV-1特异性RT抑制剂LY300046。 HCl，但齐多夫定[3'-azido-3'deoxythymidine（AZT）]不能延缓高剂量嵌合病毒感染的猕猴的血浆抗原血症的出现。用嵌合病毒感染猕猴似乎是一种有价值的模型研究新型RT抑制剂的体内功效，耐药性的出现和逆转，耐药性病毒感染的治疗以及联合治疗的功效。 [参考：38]

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