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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >THE ROLES OF COENZYME Q(10) AND VITAMIN E ON THE PEROXIDATION OF HUMAN LOW DENSITY LIPOPROTEIN SUBFRACTIONS
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THE ROLES OF COENZYME Q(10) AND VITAMIN E ON THE PEROXIDATION OF HUMAN LOW DENSITY LIPOPROTEIN SUBFRACTIONS

机译：辅酶Q（10）和维生素E对人低密度脂蛋白亚基过氧化作用的作用

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The aim of our study was to investigate the relationships between the levels of coenzyme Q(10) (CoQ(10)) and vitamin E and the levels of hydroperoxide in three subfractions of low density lipoproteins (LDL) that were isolated from healthy donors, LDL(3), the densest of the three subfractions, has shown statistically significant lower levels of CoQ(10) and vitamin E, which were associated with higher hydroperoxide levels when compared with the lighter counterparts. After CoQ(10) supplementation, all three LDL subfractions had significantly increased CoQ(10) Levels. In particular, LDL(3) showed the highest CoQ(10) increase when compared with LDL(1) and LDL(2) and was associated with a significant decrease in hydroperoxide level. These results support the hypothesis that the CoQ(10) endowment in subfractions of LDL affects their oxidizability, and they have important implications for the treatment of disease. [References: 23]
机译：我们的研究目的是调查从健康供体中分离出的三个低密度脂蛋白（LDL）亚组分中辅酶Q（10）（CoQ（10））和维生素E的水平与氢过氧化物之间的关系， LDL（3）是三个子级中最密集的部分，其CoQ（10）和维生素E含量在统计学上显着降低，与较轻的对应物相比，其氢过氧化物含量较高。补充辅酶Q（10）后，所有三个LDL子级数均显着提高了辅酶Q（10）的水平。特别是，与LDL（1）和LDL（2）相比，LDL（3）显示出最高的CoQ（10）增加，并且与氢过氧化物水平的显着降低有关。这些结果支持以下假设：低密度脂蛋白亚组分的辅酶Q（10）affect赋会影响其氧化能力，并且对疾病的治疗具有重要意义。 [参考：23]

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