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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Efficient IgG-mediated suppression of primary antibody responses 1 in Fc gamma receptor-deficient mice
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Efficient IgG-mediated suppression of primary antibody responses 1 in Fc gamma receptor-deficient mice

机译：Fcγ受体缺陷型小鼠中有效的IgG介导的初级抗体应答1的抑制

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摘要

IgG antibodies can suppress more than 99 of the antibody response against the antigen to which they bind. This is used clinically to prevent rhesus-negative (Rh-) women from becoming immunized against Rh+ erythrocytes from their fetuses. The suppressive mechanism is poorly understood, but it has been proposed that IgG/crythrocyte complexes bind to the inhibitory Fc receptor for IgG (Fcr RIIB) on the B cell surface, thereby triggering negative signals that turn off the B cell. We show that IgG induces the same degree of suppression of the response to sheep eryth- rocytfs in animals lacking the known IgG-binding receptors FcrRIIB, FcrRI + III, FcrRI + IIB + III, and FcRn (the neonatal Fc receptor) as in wild-type animals. Reinvestigation of the ability of F(ab')2 fragments to suppress antibody responses demonstrated that they were nearly as efficient as intact IgG. ln addition, monoclonal 1gE also was shown to be suppressive. These findings suggest that IgG inhibits antibody responses through Fc-independent mechanisms, most likely by masking of antigenic epitopes, thereby presenting B cells from binding and responding to antigen. In agreement with this, we show that T cell priming is not abolished by passively administered 1gG. The results have implications for the understanding of in vivo regulation of antibody responses and Rh prophylaxis.
机译：IgG抗体可以抑制针对其结合抗原的99种以上的抗体反应。这在临床上用于防止恒河猴（Rh-）妇女针对其胎儿的Rh +红细胞进行免疫。人们对抑制机制了解甚少，但有人提出，IgG /红细胞复合物与B细胞表面的IgG抑制性Fc受体（Fcr RIIB）结合，从而触发关闭B细胞的负信号。我们显示，在缺乏已知IgG结合受体FcrRIIB，FcrRI + III，FcrRI + IIB + III和FcRn（新生儿Fc受体）的动物中，IgG诱导对绵羊红细胞的反应的抑制程度相同。型动物。对F（ab'）2片段抑制抗体反应能力的再研究表明，它们几乎与完整IgG一样有效。另外，单克隆1gE也显示出抑制作用。这些发现表明，IgG通过非Fc依赖性机制抑制抗体应答，很可能是通过掩盖抗原表位，从而使B细胞与抗原结合并应答。与此相符，我们显示了被动给予1gG不会消除T细胞启动。该结果对理解抗体应答的体内调控和Rh预防具有重要意义。

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