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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Ephrin-dependent growth and pruning of hippocampal axons
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Ephrin-dependent growth and pruning of hippocampal axons

机译：Ephrin依赖的生长和修剪海马轴突。

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摘要

Neuronal connections are arranged topo- graphically such that the spatial organization of neurons is preserved by their termini in the targets. During the devel- opment of topographic projections, axons initially explore areas much wider than the final targets, and mistargeted axons are pruned later. The molecules regulating these pro- cesses are not known. We report here that the ligands of the Eph family tyrosine kinase receptors may regulate both the initial outgrowth and the subsequent pruning of axons. In the presence of ephrins, the outgrowth and branching of the receptor-positive hippocampal axons are enhanced. However, these axons are induced later to degenerate. These observa- tions suggest that the ephrins and their reccptors may regulate topographic map formation by stimulating axonal arboriza- tion and by pruning mistargcted axons.
机译：神经元连接的拓扑结构使得神经元的空间组织被其末端保留在靶标中。在地形投影的开发过程中，轴突最初探索的区域比最终目标要宽得多，而定位错误的轴突则在以后被修剪。调节这些过程的分子尚不清楚。我们在这里报告说，Eph家族酪氨酸激酶受体的配体可能调节最初的轴突生长和随后的轴突修剪。在存在麻黄素的情况下，受体阳性海马轴突的向外生长和分支增强。但是，这些轴突后来被诱导退化。这些观察结果表明，ephrin及其受体可以通过刺激轴突乔化和修剪带雾的轴突来调节地形图的形成。

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