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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cladistic association analysis of Y chromosome effects on alcohol dependence and related personality traits
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Cladistic association analysis of Y chromosome effects on alcohol dependence and related personality traits

机译：Y染色体对酒精依赖及相关人格特质影响的克拉德关联分析

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摘要

Association between Y chromosome haplo- type variation and alcohol dependence and related personality traits was investigated in a large sample of psychiatrically diagnosed Finnish males. Haplotypes were constructed for 359 individuals using alleles at eight loci (seven microsatellite loci and a nucleotide substitution in the DYZ3 alphoid satellite locus). A cladogram linking the 102 observed haplotype configurations was constructed by using parsimony with a single-step mutation model. Then, a series of contingency tables nested according to the cladogram hierarchy were used to test for association between Y haplotype and alcohol dependence. Finally, using only alcobol-dependent subjects, we tested for association between Y haplotype and personality variables postulated to define subtypes of alcoholism- antisocial personality disorder, novelty seeking, harm avoid- ance, and reward dependence. Significant association with alcohol dependence was observed at threc Y haplotype clades, with significance levels of p = 0.002, P = 0.020, and P = 0.0I0. Within alcohol-dependent subjects, no relationship was re- vealed between Y haplotype and antisocial personality disor. der, novelty seeking, harm avoidance, or reward dependence. These results demonstrate, by using a fully objective associ- ation design, that differences among Y chromosomes contrib- ute to variation in vulnerability to alcohol dependence. How- everi they do not demonstrate an association between Y haplotype and the personality variables thought to underlie the subtypes of alcoholism.
机译：在大量经精神病诊断的芬兰男性样本中，研究了Y染色体单倍型变异与酒精依赖及相关人格特征之间的关联。使用八个位点的等位基因（七个微卫星位点和DYZ3脂质卫星位点中的核苷酸取代）为359个个体构建了单倍型。通过使用简约与单步突变模型来构建链接102个观察到的单倍型构型的分支图。然后，使用一系列根据分支图层次结构嵌套的列联表来测试Y单倍型与酒精依赖之间的关联。最后，仅使用依赖醇的受试者，我们测试了Y单倍型与人格变量之间的关联，这些人格变量被假定为定义酗酒的亚型-反社会人格障碍，寻求新奇，避免伤害和奖励依赖。在threc Y单倍型进化枝上观察到与酒精依赖的显着关联，显着性水平为p = 0.002，P = 0.020和P = 0.010。在酒精依赖者中，Y单倍型与反社会人格障碍之间没有关系。寻求新颖性，避免伤害或奖励依赖。这些结果表明，通过使用完全客观的关联设计，Y染色体之间的差异导致了对酒精依赖的脆弱性的变化。但是，他们并没有证明Y型单体型与认为是酗酒亚型的人格变量之间存在关联。

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