Cytoplasmic RNA modulators of an inside-ont signal- transduction cascade

MICHAEL BLINA; WALDEMAR KOLANUS; MICHAEL FAMULOK

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Cytoplasmic RNA modulators of an inside-ont signal- transduction cascade

机译：Inside-ont信号转导级联的细胞质RNA调节剂

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摘要

A vaccinia virus-based RNA expression system enabled high-Ievel cytoplasmic expression of RNA aptamers directed against the intracellular domain of the BETA 2 integrin LFA-l, a transmembrane protein that mediates cell adhesion to intercellular adhesion molecule-l (ICAM-1). In two different cell types, cytoplasmic expression of integrin-binding aptamers reduced inducible cell adhesion to ICAM-1. The aptamers specifically target, and thereby define, a functional cytoplasmic subdomain important for the regulation of cell adhesion in leukocytes. Our approach of aptamer- controlled blocking of signaling pathways in vivo could potentially be applied wherever targeted modulation of a signal transduction cascade is desired.

机译：基于痘苗病毒的RNA表达系统使针对BETA 2整联蛋白LFA-1（一种跨膜蛋白，介导细胞与细胞间粘附分子-1（ICAM-1）的跨膜蛋白）的细胞内结构域的RNA适体能够在细胞中高表达。在两种不同的细胞类型中，整合素结合适体的胞质表达降低了诱导的细胞对ICAM-1的粘附。适体特异性地靶向并由此定义对于调节白细胞中细胞粘附重要的功能性胞质亚结构域。我们的体内适体控制信号传导途径的阻断方法可潜在地应用于需要信号转导级联的靶向调节的任何地方。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1999年第7期|3606-3610|共5页
作者
MICHAEL BLINA; WALDEMAR KOLANUS; MICHAEL FAMULOK;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
biochemistry; RNA modulators; RNA expression systems; signal-transduction cascades;

机译：生物化学RNA调节剂;RNA表达系统;信号传导级联;

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机译：FRK / RAK-SHB信号级联：调节细胞存活，分化和增殖的多功能信号转导途径。
2. MicroRNA-133 modulates the β1-adrenergic receptor transduction cascade [J] . CastaldiA., ZagliaT., DiMauroV., Circulation research: a journal of the American Heart Association . 2014,第2期

机译：MicroRNA-133调节β1-肾上腺素受体转导级联反应
3. Signal transduction by glycophorin A: role of extracellular and cytoplasmic domains in a modulatable process. [J] . J A Chasis, M E Reid, R H Jensen, Journal of cell biology . 1988,第4期

机译：糖蛋白A的信号转导：胞外域和胞质域在可调节过程中的作用。
4. The signal transduction cascade in lymphocytes during 60 Hz magnetic field exposures: calcium influx, Ca/sup +2//sub i/, pH/sub i/ and c-MYC mRNA [C] . Liburdy, R.P., Callahan, . 1993

机译：60 Hz磁场暴露期间淋巴细胞中的信号转导级联反应：钙内流，Ca / sup +2 / / sub i /，pH / sub i /和c-MYC mRNA
5. Activation of the parathyroid hormone/parathyroid hormone related peptide common receptor (PPR) modulates specific regional, temporal and signal transduction events in an avian sternal model. [D] . Harrington, Erik Kern. 2007

机译：甲状旁腺激素/甲状旁腺激素相关肽共同受体（PPR）的激活调节禽胸骨模型中的特定区域，时间和信号转导事件。
6. Cytoplasmic RNA modulators of an inside-out signal-transduction cascade [O] . Michael Blind, Waldemar Kolanus, Michael Famulok 1999

机译：由内而外的信号转导级联的细胞质RNA调节剂
7. Cytoplasmic RNA modulators of an inside-out signal-transduction cascade [O] . Blind, Michael, Kolanus, Waldemar, Famulok, Michael 1999

机译：由内而外的信号转导级联的细胞质RNA调节剂

Cytoplasmic RNA modulators of an inside-ont signal- transduction cascade

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