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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene
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Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene

机译：缺乏功能性芳香化酶（cyp 19）基因的小鼠的精子发生受损

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It is well established that spermatogenesis is controlled by gonadotrophins and testosterone. However, a role for estrogens in male reproduction recently was suggested in adult mice efficient in estrogen receptor alpha. These mice became infertile primarily because of an interruption of fluid reabsorption by the efferent ductules of the epididymis, thus leading to a disruption of the seminiferous epithelium. Despite the demonstration of the aromatase enzyme, which converts androgens to estrogens, and estrogen receptors within the rodent seminiferous epithelium, the role of aromatase and estrogen in germ cell development is unknown. We have investigated spermataogenesis in mice that lack aromatase because of the targeted disruption of the cyp19 gene (ArKO). Male mice deficient in aromatase were initially fertile but developed progressive infertility, until their ability to sire pups was severely impaired, The mice deficient in aromatase developed disruptions to spermatogenesis between 4.5 months and 1 year, despite no decreases in gonadotrophins or androgens. Spermatogenesis primarily was arrested at early spermiogenic stages, as characterized by an increase in apoptosis and the appearance of multinucletated cell, and there was a significant reduction in round and elongated spermatis, but no changes in Sertoli cells and earlier germ cells. In addition, Leydig cell hyperplasia/hypertrophy was evident, presumably as a consequence of increased circulating luteinizing hormone. Our findings indicate that local expression of aromatase is essential for spermatogenesis and provide
机译：众所周知，精子发生受促性腺激素和睾丸激素控制。但是，最近在雌激素受体α有效的成年小鼠中提出了雌激素在雄性生殖中的作用。这些小鼠的不孕症主要是由于附睾传出的导管中断了液体的再吸收，从而导致了生精上皮的破坏。尽管已经证明了芳香酶在啮齿类动物生精上皮中将雄激素转化为雌激素以及雌激素受体的作用，但是芳香酶和雌激素在生殖细胞发育中的作用尚不清楚。我们已经研究了由于cyp19基因（ArKO）的定向破坏而缺乏芳香酶的小鼠的精子发生。缺乏芳香化酶的雄性小鼠最初是可育的，但发展为不育，直到严重限制了它们的成年幼犬的能力。缺乏芳香化酶的小鼠在4.5个月至1年之间破坏了精子发生，尽管促性腺激素或雄激素没有减少。精子发生主要在早期的生精阶段停止，其特征是凋亡增加和多核细胞的出现，并且圆形和细长的精子明显减少，但Sertoli细胞和早期生殖细胞没有变化。此外，Leydig细胞增生/肥大明显，可能是由于循环黄体生成激素增加的结果。我们的发现表明，芳香化酶的局部表达对于精子发生至关重要，并提供

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