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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A subcortical pathway to the right amygdala mediating 'unseen' fear
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A subcortical pathway to the right amygdala mediating 'unseen' fear

机译：右杏仁核的皮层下通路介导“看不见的”恐惧

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摘要

Neuroimaging studies have shown differen- tial amygdala responses to masked ("unseen") emotional stimuli. How visual signals related to such unseen stimuli access the amygdala is unknown. A possible pathway, involv- ing the superior colliculus aud pulvinar, is suggested by observations of patients with striate cortex lesions who show preserved abilities to localize and discriminate visual stimuli that are not consciously perceived ("blindsight"). We used measures of right amygdala neural activity acquired from volunteer subjects viewing masked fear-conditioned faces to determine whether a colliculo-pulvinar pathway was engaged during processing of these unseen target stimuli. Increased connectivity between right amygdala, pulvinar, and superior colliculus was evident when fear-conditioned faces were un- seen rather than seen. Right amygdala connectivity with fusiform and orbitofroutal cortices decreased in the same condition. By contrast, the left amygdala, whose activity did not discriminate seen and unseen fear-conditioned targets, showed no masking-dependent changes in connectivity with superior colliculus or pulvinar. These results suggest that a subcortical pathway to the right amygdala, via midbrain and thalamus, provides a route for processing behaviorally rele- vant unseen visual events in parallel to a cortical route necessary for conscious identification.
机译：神经影像学研究表明，不同的杏仁核对被掩盖的（“看不见的”）情绪刺激有不同的反应。与这种看不见的刺激有关的视觉信号如何进入杏仁核是未知的。观察到纹状皮层病变患者表现出保留的定位和辨别未被意识察觉的视觉刺激的能力（“视力失明”），这可能是涉及上丘和丘脑的一种途径。我们使用了从志愿者受试者那里获得的右侧杏仁核神经活动的测量值，这些受试者查看戴着面具的恐惧条件下的面孔，以确定在处理这些看不见的目标刺激过程中是否参与了丘脑-脉络膜通路。当看不到恐惧的脸而不是看不到恐惧的脸时，右杏仁核，眼睑和上丘之间的连通性明显增加。在相同条件下，右扁桃体与梭形和眼眶皮质的连通性下降。相比之下，左杏仁核的活动并未区分已见和未见的恐惧条件下的目标，在与上丘或睑缘的连通性中未显示掩盖依赖性变化。这些结果表明，通过中脑和丘脑到达右杏仁核的皮层下途径提供了与意识识别所需的皮层途径平行的，处理行为上相对未见的视觉事件的途径。

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