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首页> 外文期刊>The European Journal of Neuroscience >A thalamo-cortico-amygdala pathway mediates auditory fear conditioning in the intact brain.
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A thalamo-cortico-amygdala pathway mediates auditory fear conditioning in the intact brain.

机译：丘脑-皮质-杏仁核通路介导完整大脑的听觉恐惧状态。

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摘要

The neural substrates of fear conditioning in rats have been well characterized, with converging lines of evidence indicating that conditioned stimulus (CS) and unconditioned stimulus (US) information form a CS-US association in the amygdala. Auditory CS information can reach the amygdala via two routes: a direct thalamo-amygdala pathway, and an indirect thalamo-cortico-amygdala pathway. Although either pathway can fully support learning when the alternate pathway is disrupted, many studies to date have argued that the thalamo-amygdala pathway is the principal auditory CS pathway in intact brains. To test this hypothesis, we trained rats in auditory fear conditioning, and 24 h later lesioned either pathway, leaving the alternate pathway intact. Later, animals were tested for conditioned freezing to the auditory CS. We report that lesions of the thalamo-amygdala pathway produced severe but incomplete deficits in freezing during the tone retention test, while lesions of the thalamo-cortico-amygdala pathway completely abolished freezing during tone presentation. These results suggest that the thalamo-cortico-amygdala pathway is the principal auditory CS pathway when the brain is intact.
机译：大鼠恐惧调节的神经基质已被很好地表征，证据线的融合表明条件刺激（CS）和非条件刺激（US）信息在杏仁核中形成CS-US关联。听觉CS信息可以通过两种途径到达杏仁核：直接丘脑-杏仁核途径和间接丘脑-皮质-杏仁核途径。尽管当另一种途径被破坏时，任何一种途径都可以完全支持学习，但是迄今为止，许多研究认为丘脑-杏仁核途径是完整大脑中主要的听觉CS途径。为了验证该假设，我们在听觉恐惧条件下对大鼠进行了训练，并在24小时后损伤了任一途径，而保留了另一条途径。随后，测试动物对听觉CS的条件冻结。我们报告说，丘陵-杏仁核途径的病变在语气保留测试过程中产生严重但不完全的冰冻缺陷，而丘脑-皮质-杏仁核途径的病变在语气表现期间完全消除了冻结。这些结果表明，当大脑完整时，丘脑-皮质-杏仁核通路是主要的听觉CS通路。

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