NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

Lei Ling; Zhaodan Cao; David V. Goeddel

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NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

机译：诱导NF-κB的激酶通过Ser-176的磷酸化激活IKK-α

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Activation of the transcription factor NF-κB by inflammatory cytokines involves the successive action of NF-κB-inducing kinase (NIK) and two IκB kinases, IKK-α and IKK-β. Here we show that NIK preferentially phosphor- ylates IKK-α over IKK-β, leading to the activation of IKK-α kinase activity. This phosphorylation of IKK-α occurs spe- cifically on Ser-176 in the activation loop between kinase subdomains VII and VIII. A mutant form of IKK-α containing alanine at residue 176 cannot be phosphorylated or activated by NIK and acts as a dominant negative inhibitor of inter- leukin 1- and tumor necrosis factor-induced NF-κB activation.

机译：炎症细胞因子对转录因子NF-κB的激活涉及NF-κB诱导激酶（NIK）和两个IκB激酶IKK-α和IKK-β的连续作用。在这里，我们显示NIK比IKK-β优先磷酸化IKK-α，从而导致IKK-α激酶活性被激活。 IKK-α的磷酸化特别发生在激酶亚结构域VII和VIII之间的激活环中的Ser-176上。 NIK不能将IKK-α残基176上含有丙氨酸的突变形式磷酸化或激活，它是白介素1和肿瘤坏死因子诱导的NF-κB激活的主要负性抑制剂。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1998年第7期|p.3792-3797|共6页
作者
Lei Ling; Zhaodan Cao; David V. Goeddel;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. NF-κB-Inducing Kinase Is Involved in the Activation of the CD28 Responsive Element through Phosphorylation of c-Rel and Regulation of Its Transactivating Activity [J] . Carmen Sánchez-Valdepe?as, Angel G. Martín, Parameswaran Ramakrishnan, The journal of immunology . 2006,第8期

机译：诱导NF-κB的激酶通过c-Rel的磷酸化和其反式激活活性的调节参与CD28响应元件的激活。
2. NF-κB-Inducing Kinase Is Dispensable for Activation of NF-κB in Inflammatory Settings but Essential for Lymphotoxin β Receptor Activation of NF-κB in Primary Human Fibroblasts [J] . Clive Smith, Evangelos Andreakos, James B. Crawley, The journal of immunology . 2001,第10期

机译：NF-κB诱导激酶在炎性环境中对于激活NF-κB是必不可少的，但对于原代人成纤维细胞中lymphotoxinβ受体激活NF-κB来说是必不可少的
3. Raf Kinase Inhibitor Protein Interacts with NF-κB-Inducing Kinase and TAK1 and Inhibits NF-κB Activation [J] . Kam C. Yeung, David W. Rose, Amardeep S. Dhillon, Molecular and Cellular Biology . 2001,第21期

机译：Raf激酶抑制剂蛋白与NF-κB诱导激酶和TAK1相互作用，并抑制NF-κB活化
4. Phosphorylation and Activation of 5-Lipoxvgen ase by P38 Kinase-Activated MAPKAP Kinases [C] . Oliver Werz, Jenny Klemm, Olof Radmark, International Stereotactic Radiosurgery Society . 2000

机译：P38激酶活化MapKap激酶的磷酸化和5-脂糖尿病ASE的活化
5. Molecular studies on the effects of phosphorylation by p21-activated protein kinase Pak2 on protein kinase activation and protein interactions. [D] . Jung, Jin-Hun. 2004

机译：p21激活的蛋白激酶Pak2磷酸化对蛋白激酶激活和蛋白相互作用的影响的分子研究。
6. NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176 [O] . Lei Ling, Zhaodan Cao, David V. Goeddel 1998

机译：诱导NF-κB的激酶通过Ser-176的磷酸化激活IKK-α
7. NF-κB-Inducing Kinase Is Involved in the Activation of the CD28 Responsive Element through Phosphorylation of c-Rel and Regulation of Its Transactivating Activity [O] . Carmen Sánchez-Valdepeñas, Angel G. Martín, Parameswaran Ramakrishnan, 2006

机译：NF-κB诱导激酶参与CD28响应元件的激活，通过磷酸化C-Rel和其转移活性的调节

NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

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