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首页> 外文会议>International Stereotactic Radiosurgery Society >Phosphorylation and Activation of 5-Lipoxvgen ase by P38 Kinase-Activated MAPKAP Kinases
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Phosphorylation and Activation of 5-Lipoxvgen ase by P38 Kinase-Activated MAPKAP Kinases

机译：P38激酶活化MapKap激酶的磷酸化和5-脂糖尿病ASE的活化

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5-lipoxygenase (5-LO) catalyzes the formation of leukotriene A4 from arachidonic acid. Factors determining 5-LO enzyme activity are calcium, phosphatidylcholine (membranes), ATP, and the cellular redox status. Also, a possible role of phosporylation events for 5-LO activity in the cell has been discussed. In particular, connection to the activity of protein kinase C in alveolar macrophages [1] and the effects of protein tyrosine kinase inhibitors in HL-60 cells and polymorphonuclear leukocytes (PMNL) [2] indicated such a role. The three MAP kinase families, the extracellular regulated kinases (ERKs), the c-junN-terminal kinases/stress activated protein kinases (JNKs/SAPKs), and the p38 MAP kinases, have been implicated in a variety of cellular functions, including cell proliferation, differentiation, and immune responses [3,4]. The ERKs are activated mainly by mitogens such as growth factors and G-protein coupled receptor agonists, while JNKs and p38 are activated by various types of cellular stress.For three different cell types (polymorphonuclear leukocytes, the monocytic cell line Mono Mac 6 (MM6), and the B-lymphocyte cell line BL41-E95-A) we found that upregulation of p3 8-activated MAPKAP kinases, which could phosphorylate 5-LO in vitro, occurred under conditions which also upregulated 5-LO activity of these cells. Some of the results are described in detail in reference [5].
机译：5-脂氧合酶（5-LO）催化白三烯A4的由花生四烯酸生成。确定5-LO酶活性的因素是钙，磷脂酰胆碱（膜），ATP，和细胞的氧化还原状态。此外，在小区5-LO活性磷酸化事件的可能发挥的作用进行了讨论。特别地，连接到蛋白质的活性激酶C在肺泡巨噬细胞[1]和蛋白酪氨酸激酶抑制剂在HL-60细胞和多形核白细胞（PMNL）[2]的影响指示这样的作用。三个MAP激酶家族，细胞外调节激酶（ERK），则C-junN末端激酶/应激活化蛋白激酶（JNKs信号/ SAPKs）和p38的MAP激酶，已牵涉多种细胞功能，包括细胞增殖，分化，和免疫应答[3,4]。所述的ERKs主要由活化的有丝分裂原，如生长因子和G蛋白偶联受体激动剂，而JNKs信号和p38是由各种类型的蜂窝stress.For三种不同的细胞类型（多形核白细胞，单核细胞系的Mono Mac 6的激活（MM6 ），以及B淋巴细胞细胞系BL41-E95-A），我们发现P3 8活化MAPKAP激酶的表达上调，这可能在体外磷酸化5-LO，这也上调这些细胞的5-LO活性的条件下发生的。一些结果详细描述于参考文献[5]中描述。

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