α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies

Maria Grazia Spillantini; R. Anthony Crowther; Ross Jakes

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α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies

机译：帕金森氏病和痴呆伴路易小体的路易体丝状包裹体中的α-突触核蛋白

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Lewy bodies and Lewy neurites are the de- fining neuropathological characteristics of Parkinson's dis- ease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition. We show here that Lewy bodies and Lewy neurites from Parkinson's disease and dementia with Lewy bodies are stained strongly by antibodies directed against amino- terminal and carboxyl-terminal sequences of α-synuclein, showing the presence of full-length or close to full-length α-synuclein. The number of α-synuclein-stained structures exceeded that immunoreactive for ubiquitin, which is cur- rently the most sensitive marker of Lewy bodies and Lewy neurites.

机译：路易体和路易神经突是帕金森病和路易体痴呆的定义性神经病理学特征。它们由未知成分的异常丝状组件制成。我们在这里显示帕金森氏病和路易体痴呆的路易体和路易神经突被针对α-突触核蛋白氨基末端和羧基末端序列的抗体强烈染色，显示存在全长或接近全长α-突触核蛋白。 α-突触核蛋白染色结构的数量超过了泛素的免疫反应性，泛素目前是路易小体和路易神经突的最敏感标记。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1998年第11期|p.6469-6473|共5页
作者
Maria Grazia Spillantini; R. Anthony Crowther; Ross Jakes;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. [J] . Spillantini MG, Crowther RA, Jakes R, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 1998,第3期

机译：丝状α-突触核蛋白包涵体将帕金森氏病与多系统萎缩联系在一起，路易小体与痴呆联系起来。
2. ɑ-Synuclein strains and seeding in Parkinson’s disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences [J] . W. Peelaerts, L. Bousset, V. Baekelandt, Cell and Tissue Research . 2018,第1期

机译：ɑ - 突触核蛋白菌株和帕金森病，偶然的石油体疾病，痴呆症与石油体和多种系统萎缩：相似性和差异
3. ɑ-Synuclein strains and seeding in Parkinson’s disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences [J] . W. Peelaerts, L. Bousset, V. Baekelandt, Cell and Tissue Research . 2018,第1期

机译：ɑ - 突触核蛋白菌株和帕金森病的播种，偶然的石油体疾病，痴呆症与雄鹿体和多种系统萎缩：相似性和差异
4. Module differences of glucose metabolic brain network among Alzheimer’s disease, Parkinson’s disease dementia, Lewy body dementia and health control* [C] . Danyan Chen, Jiehui Jiang, Ping Wu, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2018

机译：阿尔茨海默氏病，帕金森氏病痴呆症，路易体痴呆症和健康控制之间的葡萄糖代谢性大脑网络的模块差异*
5. Differences in caregiver grief and burden between Dementia with Lewy Bodies, dementia of the Alzheimer's type, and dementia associated with Parkinson's Disease [D] . Rigby, Taylor. 2016

机译：路易体痴呆，阿尔茨海默氏型痴呆和帕金森氏病相关的痴呆之间照料者的悲伤和负担的差异
6. α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies [O] . Maria Grazia Spillantini, R. Anthony Crowther, Ross Jakes, 1998

机译：帕金森氏病和痴呆伴有路易小体的路易体丝状包裹体中的α-突触核蛋白
7. Tissue transglutaminase-induced aggregation of α-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies [O] . Junn, Eunsung, Ronchetti, Ruben D., Quezado, Martha M., 2003

机译：组织转谷氨酰胺酶诱导的α-突触核蛋白聚集：对帕金森氏病和路易小体痴呆中路易小体形成的影响

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies

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