ATM binds to -adaptin in cytoplasmic vesicles

Dae-Sik Lim; David G. Kirsch; Christine E. Canman

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ATM binds to -adaptin in cytoplasmic vesicles

机译：ATM与细胞质囊泡中的-adaptin结合

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Inherited mutations in the ATM gene lead to a complex clinical phenotype characterized by neuronal de- eneration, oculocutaneous telangiectasias, immune dysfunc- tion, and cancer predisposition. Using the yeast two-hybrid system, we demonstrate that ataxia telangiectasia mutated (ATM) binds to β-adaptin, one of the components of the AP-2 adaptor complex, which is involved in clathrin-mediated endocytosis of receptors. The interaction between ATM and β-adaptin was confirmed in vitro, and coimmunoprecipitation and colocalization studies show that the proteins also asso- ciate in vivo. ATM also interacts in vitro with β-NAP, a neuronal-specific β-adaptin homolog that was identified as an autoantigen in a patient with cerebellar degeneration.

机译：ATM基因的遗传突变会导致复杂的临床表型，其特征是神经元变性，眼皮肤毛细血管扩张，免疫功能低下和癌症易感性。使用酵母双杂交系统，我们证明了共济失调毛细血管扩张突变（ATM）绑定到AP-2适配器复杂，参与网格蛋白介导的受体内吞的组件之一的β-adaptin。在体外证实了ATM和β-适应素之间的相互作用，并且共免疫沉淀和共定位研究表明，蛋白质也与体内相关。 ATM还可以与β-NAP进行体外相互作用，β-NAP是一种神经元特异性β-adaptin同源物，在小脑变性患者中被鉴定为自身抗原。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1998年第17期|p.10146-10151|共6页
作者
Dae-Sik Lim; David G. Kirsch; Christine E. Canman;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. ATM binds to β-adaptin in cytoplasmic vesicles [O] . Dae-Sik Lim, David G. Kirsch, Christine E. Canman, 1998

机译：ATM与细胞质囊泡中的β-adaptin结合
7. ATM binds to -adaptin in cytoplasmic vesicles [O] . D.-S. Lim, D. G. Kirsch, C. E. Canman, 1998

机译：ATM与细胞质囊泡中的-Adaptin结合
8. Inducible Cytoplasmic Factor (AU-B) Binds Selectively to AUUUA Multimers in the3' Untranslated Region of Lymphokine mRNA [R] . Boujanen, P. R., Petryniak, B., June, C. H., 1991

机译：诱导型细胞质因子（aU-B）选择性结合淋巴因子mRNa 3'非翻译区的aUUUa多聚体

ATM binds to -adaptin in cytoplasmic vesicles

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