Specific requirement for CD3εin T cell development

Jan B. DeJarnette; Connie L. Sommers; Kun Huang

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Specific requirement for CD3εin T cell development

机译：CD3ε在T细胞发育中的特殊要求

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摘要

T cell antigen receptor (TCR) and pre-TCR complexes are composed of clonotypic heterodimers in asso- ciation with dimers of signal transducing invariant subunits (CD3γ, -δ, -ε, and ζ). The role of individual invariant subunits in T cell development has been investigated by generating gene-specific mutations in mice. Mutation of CD3γ, -δ, orζ results in an incomplete block in development, characterized by reduced numbers of mature T cells that express low levels of TCR. In contrast, mature T cells are absent from CD3ε~-/- mice, and thymocyte development is arrested at the early CD4~-CD8~- stage.

机译：T细胞抗原受体（TCR）和pre-TCR复合物由克隆型异二聚体与信号转导恒定亚基（CD3γ，-δ，-ε和ζ）的二聚体组成。通过在小鼠中产生基因特异性突变，已经研究了各个不变亚基在T细胞发育中的作用。 CD3γ，-δ或ζ突变会导致发育中的不完整区域，其特征是表达低水平TCR的成熟T细胞数量减少。相反，CD3ε-/-小鼠缺乏成熟的T细胞，胸腺细胞的发育在CD4--CD8--早期被阻止。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1998年第25期|p.14909-14914|共6页
作者
Jan B. DeJarnette; Connie L. Sommers; Kun Huang;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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Specific requirement for CD3εin T cell development

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