A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter

Jose Tapia-Ramirez; Bart J. L. Eggen; Maria J. Peral-Rubio

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A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter

机译：沉默因子REST中的单个锌指基序可抑制神经特异性II型钠通道启动子

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The type II voltage-dependent sodium chan- nel is present in neuronal cells, where it mediates the prop- agation of nerve impulses. Restricted expression of the type II sodium channel gene to neurons is due, at least in part, to binding of the repressor protein REST (also termed NRSF or XBR) to the RE1 (also called NRSE) sequence in the type II sodium channel gene. Previous studies have shown that a domain in REST containing eight GL1-Kr¨1ppel zinc finger motifs mediates DNA binding.

机译：II型电压依赖性钠通道存在于神经元细胞中，在其中介导神经脉冲的传播。 II型钠通道基因对神经元的限制表达至少部分归因于阻遏蛋白REST（也称为NRSF或XBR）与II型钠通道基因中的RE1（也称为NRSE）序列的结合。先前的研究表明，REST中包含八个GL1-Kr¨1ppel锌指基序的结构域介导DNA结合。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第4期|p.1177-1182|共6页
作者
Jose Tapia-Ramirez; Bart J. L. Eggen; Maria J. Peral-Rubio;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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2. PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters [J] . Akihide TAKEUCHI, Hengyi XIAO, Jalin MAO, The biochemical journal . 2000,第1期

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3. Kruppel-like Factor 15, a Zinc-Finger Transcriptional Regulator, Represses the Rhodopsin and Interphotoreceptor Retinoid-Binding Protein Promoters. [J] . Otteson DC, Liu Y, Lai H, Investigative ophthalmology & visual science . 2004,第8期

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6. A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter [O] . José Tapia-Ramírez, Bart J. L. Eggen, Maria J. Peral-Rubio, 1997

机译：沉默因子REST中的单个锌指基序抑制神经特异性II型钠通道启动子
7. A Single Zinc Finger Motif in the Silencing Factor Rest Represses the Neural-Specific Type II Sodium Channel Promoter. [O] . Peral Rubio, María José, Tapia Ramírez, José, Eggen, Bart J L, 1997

机译：沉默因子中的单个锌指基序会抑制特定于神经的II型钠通道启动子。

A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter

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