Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets

G. Barba; F. Harper; T. Harada

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Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets

机译：丙型肝炎病毒核心蛋白显示胞质定位并与细胞脂质储存液滴相关

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There is now abundant evidence to substan- tiate an important role of hepatitis C virus (HCV) core protein in cellular gene expression as well as in the viral cycle. Thus the subcellular localization of this protein has important implications. However, several studies have shown controver- sial results: the HCV core has been, indeed, described as cytoplasmic or nuclear depending on the size of the protein or on the genotype analyzed. We have studied the localization of the HCV core protein in two different cell lines, one nonhe- patic (CHO) and the other hepatic (HepG2).

机译：现在有大量证据证明丙型肝炎病毒（HCV）核心蛋白在细胞基因表达以及病毒循环中起着重要作用。因此，该蛋白的亚细胞定位具有重要意义。但是，一些研究显示了有争议的结果：HCV核心确实根据蛋白质的大小或所分析的基因型被描述为胞质的或核的。我们已经研究了HCV核心蛋白在两种不同细胞系中的定位，一种是非肝细胞（CHO），另一种是肝细胞（HepG2）。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第4期|p.1200-1205|共6页
作者
G. Barba; F. Harper; T. Harada;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein [J] . Sato S, Fukasawa M, Yamakawa Y, The Journal of Biochemistry . 2006,第5期

机译：表达丙型肝炎病毒核心蛋白的肝癌细胞系中脂质滴蛋白的蛋白质组学分析
2. Proteomic Profiling of Lipid Droplet Proteins in Hepatoma Cell Lines Expressing Hepatitis C Virus Core Protein [J] . Shigeko Sato1 Masayoshi Fukasawa1, Yoshio Yamakawa1 Tohru Natsume2, Tetsuro Suzuki3 Ikuo Shoji3 Hideki Aizaki3 Tatsuo Miyamura3 and Masahiro Nishijima1† Journal of Biochemistry . 2006,第5期

机译：表达丙型肝炎病毒核心蛋白的肝癌细胞系中脂滴蛋白的蛋白质组学分析
3. The Hepatitis C Virus Core Protein Inhibits Adipose Triglyceride Lipase (ATGL)-mediated Lipid Mobilization and Enhances the ATGL Interaction with Comparative Gene Identification 58 (CGI-58) and Lipid Droplets [J] . Gregory Camus, Martina Schweiger, Eva Herker, The Journal of biological chemistry . 2014,第52期

机译：丙型肝炎病毒核心蛋白抑制脂肪甘油三酯脂肪酶（ATGL）介导的脂质摩托，并增强与对比基因鉴定58（CGI-58）和脂液滴的ATG1相互作用
4. Cellular gene expression profiles induced by hepatitis C virus short core protein in Huh-7 cell line [C] . . 2005

机译：丙型肝炎病毒短核蛋白在Huh-7细胞系中诱导的细胞基因表达谱
5. Chimeric orthohepadnavirus core particles for oral delivery of vaccines: Part I. Transformation of tobacco plants with a gene encoding a c-terminus truncated hepatitis B virus core protein. Part II. Construction of a woodchuck hepatitis virus core protein-based universal epitope carrier and test expression in Escherichia coli. [D] . Callaghan, Maximilian W. 2001

机译：用于口服递送疫苗的嵌合正丙肝病毒核心颗粒：第一部分。用编码c末端截短的乙型肝炎病毒核心蛋白的基因转化烟草植物。第二部分基于土拨鼠肝炎病毒核心蛋白的通用表位载体的构建和大肠杆菌中的表达测试。
6. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets [O] . G. Barba, F. Harper, T. Harada, 1997

机译：丙型肝炎病毒核心蛋白显示胞质定位并与细胞脂质存储相关
7. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets [O] . G. Barba, F. Harper, T. Harada, 1997

机译：丙型肝炎病毒核心蛋白显示细胞质定位，并与细胞脂质储存液滴相关联

Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets

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