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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Single-chain fusions of two unrelated homeodomain proteins trigger pathogenicity in Ustilago maydis
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Single-chain fusions of two unrelated homeodomain proteins trigger pathogenicity in Ustilago maydis

机译：两种不相关的同源域蛋白的单链融合触发了乌斯地亚哥的致病性

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摘要

Pathogenic and sexual development of the fungus Ustilago maydis, the causal agent of corn smut disease, is regulated by heterodimerization of two unrelated homeodo- main proteins bE and bW, both encoded by the multi-allelic b mating-type locus. This complex can only be formed if the two proteins are derived from different alleles. The heterodimer is believed to function as a transcriptional regulator that binds to target sites upstream of developmentally regulated genes. We have synthesized a translational fusion in which bE is tethered to bW by a designed flexible kink region.
机译：玉米黑穗病的病原体Ustilago maydis的病原性和性发育受到两个无关的同源主蛋白bE和bW异二聚化的调节，这两种蛋白均由多等位基因b交配型基因座编码。仅当两种蛋白质均来自不同等位基因时，才能形成这种复合物。据信异二聚体起与转录调控因子结合的作用，该转录调控因子与发育调控基因上游的靶位点结合。我们合成了翻译融合，其中bE通过设计的柔性纽结区域与bW相连。

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