Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein

Diane D. Murphy; Menahem Segal

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Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein

机译：cAMP反应元件结合蛋白的激活介导树突棘在中枢神经元中的形态可塑性

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While evidence has accumulated in favor of cAMP-associated genomic involvement in long-term synaptic plasticity, the mechanisms downstream of the activated nu- cleus that underlie these changes in neuronal function remain mostly unknown. Dendritic spines, the locus of excitatory interaction among central neurons, are prime candidates for long-term synaptic modifications. We now present evidence that links phosphorylation of the cAMP response element binding protein (CREB) to formation of new spines; exposure to estradiol doubles the density of dendritic spines in cultured hippocampal neurons, and concomitantly causes a large increase in phosphorylated CREB and in CREB binding protein.

机译：尽管有证据表明，与cAMP相关的基因组参与了长期突触可塑性，但激活核下游的基础是这些神经元功能变化的基础机制仍然未知。树突棘是中枢神经元之间兴奋性相互作用的场所，是长期突触修饰的主要候选对象。我们现在提出证据，将cAMP反应元件结合蛋白（CREB）的磷酸化与新棘的形成联系起来；暴露于雌二醇会使培养的海马神经元中树突棘的密度增加一倍，并随之导致磷酸化CREB和CREB结合蛋白的大量增加。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第4期|p.1482-1487|共6页
作者
Diane D. Murphy; Menahem Segal;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. [J] . Kawasaki Y, Kohno T, Zhuang ZY, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2004,第38期

机译：离子型和代谢型受体，蛋白激酶A，蛋白激酶C和Src有助于C纤维诱导的ERK活化和背角神经元中cAMP反应元件结合蛋白的磷酸化，从而导致中枢敏化。
2. 17beta-estradiol induces Ca2+ influx, dendritic and nuclear Ca2+ rise and subsequent cyclic AMP response element-binding protein activation in hippocampal neurons: a potential initiation mechanism for estrogen neurotrophism. [J] . Zhao L, Chen S, Ming Wang J, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2005,第2期

机译：17β-雌二醇在海马神经元中诱导Ca2 +流入，树突状和核Ca2 +升高以及随后的环AMP响应元件结合蛋白激活：雌激素神经营养的潜在启动机制。
3. Integrins control dendritic spine plasticity in hippocampal neurons through NMDA receptor and Ca2+/calmodulin-dependent protein kinase II-mediated actin reorganization. [J] . Shi Y, Ethell IM The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2006,第6期

机译：整联蛋白通过NMDA受体和Ca2 + /钙调蛋白依赖性蛋白激酶II介导的肌动蛋白重组来控制海马神经元的树突棘可塑性。
4. Segmentation and assessment of structural plasticity of hippocampal dendritic spines from 3D confocal light microscopy [C] . Subhadip Basu, Punam Kumar Saha, Ewa Baczynska, SPIE Medical Imaging Conference . 2018

机译：从3D共聚焦光学显微镜分割和评估海马树突棘的结构可塑性
5. The Polyadenosine RNA Binding Protein ZC3H14 Is Required in Mice for Proper Working Memory, Synaptosomal Composition, and Dendritic Spine Density and Morphology [D] . Jones, Stephanie. 2020

机译：小鼠中需要聚萘氨酸RNA结合蛋白ZC3H14，用于适当的工作记忆，突触体组合物和树突状脊柱密度和形态学
6. Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein [O] . Diane D. Murphy, Menahem Segal 1997

机译：cAMP反应元件结合蛋白的激活介导树突棘在中枢神经元中的形态可塑性
7. Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein [O] . Murphy, Diane D., Segal, Menahem 1997

机译：cAMP反应元件结合蛋白的激活介导树突棘在中枢神经元中的形态可塑性
8. Activation of Mitogen-Activated Protein Kinases and Cyclic Amp Response Element-Binding Protein in Synaptic Plasticity. [R] . Voulalas, P. J. 1997

机译：突触可塑性中丝裂素活化蛋白激酶和环状放大器反应元件结合蛋白的激活。

Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein

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