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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >COOPERATIVE EFFECTS OF PHOTODYNAMIC TREATMENT OF CELLS IN MICROCOLONIES
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COOPERATIVE EFFECTS OF PHOTODYNAMIC TREATMENT OF CELLS IN MICROCOLONIES

机译：光殖民地细胞光合作用的协同作用

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摘要

Microcolonies of 2-8 Madison-Darby canine kidney cells (MDCK II) and Chinese hamster lung fibroblasts (V79) cells were incubated with the photosensitizer Photofrin and exposed to light, and the resulting number of dead cells per colony was determined, The distribution of this number was found to be incompatible with the assumption that cells are inactivated independently, The experimental distributions were significantly different from the binomial distribution expected from this assumption, but in accordance with a model in which an inactivated cell can inactivate adjacent cells with a certain probability, These findings are contrary to the common view that damage caused by radiation is limited to the cell in which the primary damage takes place, Our findings clearly indicate some kind of cooperativity between cells treated with Photofrin and light. [References: 15]
机译：将2-8个Madison-Darby犬肾细胞（MDCK II）和中国仓鼠肺成纤维细胞（V79）细胞的微菌落与光敏剂Photofrin孵育并暴露于光线下，确定每个菌落的死细胞数，发现该数字与细胞独立失活的假设不符。实验分布与根据该假设预期的二项式分布有显着差异，但是根据一个模型，其中失活的细胞可以一定的概率灭活相邻的细胞，这些发现与通常的观点相反，即由辐射引起的损害仅限于发生原发性损害的细胞。我们的发现清楚地表明了用光敏蛋白和光处理的细胞之间存在某种协同作用。 [参考：15]

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