A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor α chain

Yonghong Wang; Bo-Jiang Shen; Walter Sebald

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A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor α chain

机译：人白介素4中的混合电荷对控制与受体α链的高亲和力相互作用

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Human interleukin 4 (IL-4) binds to its cellular receptor with a K_d in the subnanomolar range, similar to many other 4-helix-bundle proteins interacting with mem- bers of the hematopoietin (cytokine) receptor superfamily. In the IL-4 system this interaction is predominantly determined by the extracellular domain (IL4-BP) of the receptor chain (K_d ≈ 150 pM). Now a high-resolution mutational and kinetic analysis has revealed that the high-affinity binding of IL-4 originates from a continuous patch of a few mostly polar or charged amino acid side chains located on helices A and C.

机译：人白介素4（IL-4）以亚纳摩尔范围内的K_d与其细胞受体结合，类似于许多其他与造血素（细胞因子）受体超家族成员相互作用的4-螺旋束蛋白。在IL-4系统中，这种相互作用主要取决于受体链的胞外域（IL4-BP）（K_d≈150 pM）。现在，高分辨率的突变和动力学分析表明，IL-4的高亲和力结合来自位于螺旋A和C上的几个极性或带电氨基酸侧链的连续补片。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第5期|p.1657-1662|共6页
作者
Yonghong Wang; Bo-Jiang Shen; Walter Sebald;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. A MIXED-CHARGE PAIR IN HUMAN INTERLEUKIN 4 DOMINATES HIGH-AFFINITY INTERACTION WITH THE RECEPTOR ALPHA CHAIN [J] . Wang YH., Sebald W., Shen BJ. Proceedings of the National Academy of Sciences of the United States of America . 1997,第5期

机译：人类白细胞介素4的混合电荷对决定了与受体链的高亲和力相互作用
2. Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding. [J] . F C Stomski, Q Sun, C J Bagley, Molecular and Cellular Biology . 1996,第6期

机译：人白介素3（IL-3）诱导二硫键连接的IL-3受体α和β链异二聚，这是受体激活所必需的，但不是高亲和力结合。
3. Phenotypic knockout of the high-affinity human interleukin 2 receptor by intracellular single-chain antibodies against the alpha subunit of the receptor. [J] . Richardson JH, Sodroski JG, Waldmann TA, Proceedings of the National Academy of Sciences of the United States of America . 1995,第8期

机译：高亲和力人类白细胞介素2受体的表型敲除，针对该受体的α亚基的细胞内单链抗体。
4. Building Robust and Simple Cell-Based Assays for Interleukins and Their Receptors [C] . Jane E. Lamerdin, Hyna Dotimas, Sangeetha Gunthuri, Protein Engineering Summit. . 2018

机译：为白细胞介素及其受体构建鲁棒和基于细胞的基于细胞的测定
5. The interaction of human benign neoplasms with the growth regulating protein, interleukin-6 (IL-6) and its surface receptor IL-6R. [D] . Paino, Javier E. 2005

机译：人类良性肿瘤与生长调节蛋白白介素-6（IL-6）及其表面受体IL-6R的相互作用。
6. A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor α chain [O] . Yonghong Wang, Bo-Jiang Shen, Walter Sebald 1997

机译：人白介素4中的混合电荷对主导与受体α链的高亲和力相互作用
7. Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding. [O] . Stomski, F C, Sun, Q, Bagley, C J, 1996

机译：人白介素3（IL-3）诱导二硫键连接的IL-3受体α和β链异二聚，这是受体激活所必需的，但不是高亲和力结合。

A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor α chain

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