Glutathione deficiency is associated with impaired survival in HIV disease

Leonore A. Herzenberg; Stephen C. De Rosa; J. Gregson Dubs

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Glutathione deficiency is associated with impaired survival in HIV disease

机译：谷胱甘肽缺乏症与HIV疾病的生存受损有关

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Glutathione (GSH), a cysteine-containing tripeptide, is essential for the viability and function of virtu- ally all cells. In vitro studies showing that low GSH levels both promote HIV expression and impair T cell function suggested a link between GSH depletion and HIV disease progression. Clinical studies presented here directly demonstrate that low GSH levels predict poor survival in otherwise indistinguish- able HIV-infected subjects.

机译：谷胱甘肽（GSH）是一种含半胱氨酸的三肽，对于几乎所有细胞的生存和功能至关重要。体外研究表明，低GSH含量可促进HIV表达并损害T细胞功能，提示GSH耗竭与HIV疾病进展之间存在联系。本文介绍的临床研究直接表明，低GSH水平可预测在其他情况下无法区分的HIV感染者的不良生存。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第5期|p.1967-1972|共6页
作者
Leonore A. Herzenberg; Stephen C. De Rosa; J. Gregson Dubs;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. GLUTATHIONE DEFICIENCY IS ASSOCIATED WITH IMPAIRED SURVIVAL IN HIV DISEASE [J] . Herzenberg LA., Dubs JG., Roederer M., Proceedings of the National Academy of Sciences of the United States of America . 1997,第5期

机译：谷胱甘肽缺乏症与HIV疾病的生存率降低有关
2. Glutathione Deficiency in Hiv-Infected Patients: A True or Technical Deficiency? [J] . A M Breckenridge, B K Park, D Williams, Clinical Science . 1996,第s35期

机译：HIV感染患者的谷胱甘肽缺乏症：真正的还是技术性缺乏？
3. Survival analysis of acquired immune deficiency syndrome patients with and without hepatitis C virus infection at a reference center for sexually transmitted diseases/acquired immune deficiency syndrome in S?o Paulo, Brazil [J] . Eliseu Alves Waldman, Paulo Schiavom Duarte, Wong Kuen Alencar Brazilian Journal of Infectious Diseases . 2014,第2期

机译：巴西圣保罗性传播疾病/后天免疫缺陷综合症参考中心对获得性和缺乏丙型肝炎病毒感染的获得性免疫缺陷综合症患者的生存分析
4. Applications of Phase Type Survival Trees in HIV Disease Progression Modelling [C] . Marija Gafa, Lalit Garg, Giovanni Masala, International Conference on Computational Science and Its Applications . 2017

机译：相型存活树木在艾滋病毒疾病进展模型中的应用
5. Associations of T-cell phenotypes with persistent oral thrush at CD4 positive cell counts greater than 500 per cubic millimeter and their interactions with progression of HIV disease (Immune deficiency). [D] . Foster, Virginia Brown. 2001

机译：T细胞表型与持续口鹅口疮在CD4阳性细胞数上的关联大于每立方毫米500，以及它们与HIV疾病进展（免疫缺陷）的相互作用。
6. Glutathione deficiency is associated with impaired survival in HIV disease [O] . Leonore A. Herzenberg, Stephen C. De Rosa, J. Gregson Dubs, 1997

机译：谷胱甘肽缺乏症与HIV疾病的生存受损有关
7. Glutathione deficiency is associated with impaired survival in HIV disease [O] . L. A. Herzenberg, S. C. De Rosa, J. G. Dubs, 1997

机译：谷胱甘肽缺乏与艾滋病毒疾病的存活受损有关

Glutathione deficiency is associated with impaired survival in HIV disease

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